<italic toggle="yes">MetaMed</italic>: Linking Microbiota Functions with Medicine Therapeutics

Han Zhao; Shaliu Fu; Yifei Yu; Zhanbing Zhang; Ping Li; Qin Ma; Wei Jia; Kang Ning; Shen Qu; Qi Liu

doi:10.1128/mSystems.00413-19

mSystems (Oct 2019)

<italic toggle="yes">MetaMed</italic>: Linking Microbiota Functions with Medicine Therapeutics

Han Zhao,
Shaliu Fu,
Yifei Yu,
Zhanbing Zhang,
Ping Li,
Qin Ma,
Wei Jia,
Kang Ning,
Shen Qu,
Qi Liu

Affiliations

Han Zhao: Department of Endocrinology and Metabolism, Shanghai Tenth People’s Hospital, and Bioinformatics Department, School of Life Sciences and Technology, Tongji University, Shanghai, China
Shaliu Fu: Department of Endocrinology and Metabolism, Shanghai Tenth People’s Hospital, and Bioinformatics Department, School of Life Sciences and Technology, Tongji University, Shanghai, China
Yifei Yu: Department of Endocrinology and Metabolism, Shanghai Tenth People’s Hospital, and Bioinformatics Department, School of Life Sciences and Technology, Tongji University, Shanghai, China
Zhanbing Zhang: Department of Endocrinology and Metabolism, Shanghai Tenth People’s Hospital, and Bioinformatics Department, School of Life Sciences and Technology, Tongji University, Shanghai, China
Ping Li: Department of Endocrinology and Metabolism, Shanghai Tenth People’s Hospital, and Bioinformatics Department, School of Life Sciences and Technology, Tongji University, Shanghai, China
Qin Ma: Department of Mathematics and Statistics, South Dakota State University, Brookings, South Dakota, USA
Wei Jia: R&D Information, Innovation Center China, AstraZeneca, Shanghai, China
Kang Ning: School of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China
Shen Qu: Department of Endocrinology and Metabolism, Shanghai Tenth People’s Hospital, and Bioinformatics Department, School of Life Sciences and Technology, Tongji University, Shanghai, China
Qi Liu: Department of Endocrinology and Metabolism, Shanghai Tenth People’s Hospital, and Bioinformatics Department, School of Life Sciences and Technology, Tongji University, Shanghai, China

DOI: https://doi.org/10.1128/mSystems.00413-19
Journal volume & issue: Vol. 4, no. 5

Abstract

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ABSTRACT Understanding how the human microbiome affects human health has consequences for treating disease and minimizing unwanted side effects in clinical research. Here, we present MetaMed (http://metamed.rwebox.com/index), a novel and integrative system-wide correlation mapping system to link bacterial functions and medicine therapeutics, providing novel hypotheses for deep investigation of microbe therapeutic effects on human health. Furthermore, comprehensive relationships between microbes living in the environment and drugs were discovered, providing a rich source for discovering microbiota metabolites with great potential for pharmaceutical applications.

Published in mSystems

ISSN: 2379-5077 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/msystems

About the journal

Abstract

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