INFLAMMATION AND SEPSIS BIOMARKERS IN DIAGNOSIS OF THE GENERALIZED PERITONITIS STAGE

Abstract

Objective: To assess the predictable role of inflammatory biomarkers in determining the stage of generalized peritonitis. Methods: The study included 160 patients with generalized peritonitis. All patients were assigned to three groups depending on the stages of the peritonitis. Once, on the first day after the patient’s admission to the hospital, investigated the concentration of the main inflammation markers in the blood serum. Results: The maximum levels of biomarkers were found in patients with septic shock (group 3). The lowest average value and minimum concentration were detected in patients with generalized peritonitis in the endogenous intoxication stage. The presepsin test has a high degree of sensitivity (96.2%) and acceptable specificity (90.9%). The test for procalcitonin showed less sensitivity and specificity – 91.9 and 87.9%, respectively. The values of sensitivity and specificity of C-reactive protein and interleukin-6 in our study are slightly lower: 90%, 81.9%, and 90.9%, 84.8%, respectively. A strong correlation between biomarkers and the stage of the disease is noted. In this case, the strongest relationship was found in prespepsin (r=0.9194). Conclusion: A reliable relationship between the severity of the extent of peritonitis and the level of presepsin in the blood was found, which allows for effective use of its value in the diagnosis of abdominal sepsis. The use of the complex of biomarkers has a higher value. The results we have obtained indicate the prospect character of using the presepsin test in combination with other markers of inflammation in surgical practice.

Keywords

• generalized peritonitis
• abdominal sepsis
• biomarkers of sepsis
• presepsin
• prediction.