In-depth comparison of the metabolic and pharmacokinetic behaviour of the structurally related synthetic cannabinoids AMB-FUBINACA and AMB-CHMICA in rats

David Fabregat-Safont; María Mata-Pesquera; Manuela Barneo-Muñoz; Ferran Martinez-Garcia; Marie Mardal; Anders B. Davidsen; Juan V. Sancho; Félix Hernández; María Ibáñez

doi:10.1038/s42003-022-03113-5

Communications Biology (Feb 2022)

In-depth comparison of the metabolic and pharmacokinetic behaviour of the structurally related synthetic cannabinoids AMB-FUBINACA and AMB-CHMICA in rats

David Fabregat-Safont,
María Mata-Pesquera,
Manuela Barneo-Muñoz,
Ferran Martinez-Garcia,
Marie Mardal,
Anders B. Davidsen,
Juan V. Sancho,
Félix Hernández,
María Ibáñez

Affiliations

David Fabregat-Safont: Environmental and Public Health Analytical Chemistry, Research Institute for Pesticides and Water (IUPA), University Jaume I
María Mata-Pesquera: Environmental and Public Health Analytical Chemistry, Research Institute for Pesticides and Water (IUPA), University Jaume I
Manuela Barneo-Muñoz: Predepartmental Unit of Medicine, Unitat Mixta de Neuroanatomia Funcional NeuroFun-UVEG-UJI, University Jaume I
Ferran Martinez-Garcia: Predepartmental Unit of Medicine, Unitat Mixta de Neuroanatomia Funcional NeuroFun-UVEG-UJI, University Jaume I
Marie Mardal: Section of Forensic Chemistry, Department of Forensic Medicine, University of Copenhagen
Anders B. Davidsen: Section of Forensic Chemistry, Department of Forensic Medicine, University of Copenhagen
Juan V. Sancho: Environmental and Public Health Analytical Chemistry, Research Institute for Pesticides and Water (IUPA), University Jaume I
Félix Hernández: Environmental and Public Health Analytical Chemistry, Research Institute for Pesticides and Water (IUPA), University Jaume I
María Ibáñez: Environmental and Public Health Analytical Chemistry, Research Institute for Pesticides and Water (IUPA), University Jaume I

DOI: https://doi.org/10.1038/s42003-022-03113-5
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 13

Abstract

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Synthetic cannabinoids are amongst the most widely used psychoactive drugs which are tightly controlled by government agencies around the world. Here, pharmacokinetics of two synthetic cannabinoids in rats are evaluated along with their metabolites and tissue distribution, aiding in identifying distinct biomarkers that reflect the consumption of synthetic cannabinoids based on the tissue.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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