Nature Communications (Jul 2020)
Co-option of Plasmodium falciparum PP1 for egress from host erythrocytes
- Aditya S. Paul,
- Alexandra Miliu,
- Joao A. Paulo,
- Jonathan M. Goldberg,
- Arianna M. Bonilla,
- Laurence Berry,
- Marie Seveno,
- Catherine Braun-Breton,
- Aziz L. Kosber,
- Brendan Elsworth,
- Jose S. N. Arriola,
- Maryse Lebrun,
- Steven P. Gygi,
- Mauld H. Lamarque,
- Manoj T. Duraisingh
Affiliations
- Aditya S. Paul
- Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health
- Alexandra Miliu
- Laboratory of Pathogen Host Interaction (LPHI), UMR5235, Centre National de la Recherche Scientifique (CNRS), Université de Montpellier
- Joao A. Paulo
- Department of Cell Biology, Harvard Medical School
- Jonathan M. Goldberg
- Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health
- Arianna M. Bonilla
- Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health
- Laurence Berry
- Laboratory of Pathogen Host Interaction (LPHI), UMR5235, Centre National de la Recherche Scientifique (CNRS), Université de Montpellier
- Marie Seveno
- Laboratory of Pathogen Host Interaction (LPHI), UMR5235, Centre National de la Recherche Scientifique (CNRS), Université de Montpellier
- Catherine Braun-Breton
- Laboratory of Pathogen Host Interaction (LPHI), UMR5235, Centre National de la Recherche Scientifique (CNRS), Université de Montpellier
- Aziz L. Kosber
- Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health
- Brendan Elsworth
- Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health
- Jose S. N. Arriola
- Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health
- Maryse Lebrun
- Laboratory of Pathogen Host Interaction (LPHI), UMR5235, Centre National de la Recherche Scientifique (CNRS), Université de Montpellier
- Steven P. Gygi
- Department of Cell Biology, Harvard Medical School
- Mauld H. Lamarque
- Laboratory of Pathogen Host Interaction (LPHI), UMR5235, Centre National de la Recherche Scientifique (CNRS), Université de Montpellier
- Manoj T. Duraisingh
- Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health
- DOI
- https://doi.org/10.1038/s41467-020-17306-1
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 13
Abstract
Plasmodium protein phosphatase PP1 is essential for the asexual proliferation of malaria parasites. Here the authors show that PP1 regulates egress of parasites from host red blood cells, integrating parasite intrinsic pathways with environmental signals for release into the bloodstream.
