TGF-β-dependent lymphoid tissue residency of stem-like T cells limits response to tumor vaccine

Guo Li; Saranya Srinivasan; Liwen Wang; Chaoyu Ma; Kai Guo; Wenhao Xiao; Wei Liao; Shruti Mishra; Xin Zhang; Yuanzheng Qiu; Qianjin Lu; Yong Liu; Nu Zhang

doi:10.1038/s41467-022-33768-x

Nature Communications (Oct 2022)

TGF-β-dependent lymphoid tissue residency of stem-like T cells limits response to tumor vaccine

Guo Li,
Saranya Srinivasan,
Liwen Wang,
Chaoyu Ma,
Kai Guo,
Wenhao Xiao,
Wei Liao,
Shruti Mishra,
Xin Zhang,
Yuanzheng Qiu,
Qianjin Lu,
Yong Liu,
Nu Zhang

Affiliations

Guo Li: Department of Microbiology, Immunology and Molecular Genetics, Long School of Medicine, University of Texas Health Science Center at San Antonio
Saranya Srinivasan: Department of Microbiology, Immunology and Molecular Genetics, Long School of Medicine, University of Texas Health Science Center at San Antonio
Liwen Wang: Department of Microbiology, Immunology and Molecular Genetics, Long School of Medicine, University of Texas Health Science Center at San Antonio
Chaoyu Ma: Department of Microbiology, Immunology and Molecular Genetics, Long School of Medicine, University of Texas Health Science Center at San Antonio
Kai Guo: Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University
Wenhao Xiao: Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University
Wei Liao: Department of Microbiology, Immunology and Molecular Genetics, Long School of Medicine, University of Texas Health Science Center at San Antonio
Shruti Mishra: Department of Microbiology, Immunology and Molecular Genetics, Long School of Medicine, University of Texas Health Science Center at San Antonio
Xin Zhang: Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University
Yuanzheng Qiu: Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University
Qianjin Lu: Department of Dermatology, Hunan Key Laboratory of Medical Epigenomics, The Second Xiangya Hospital, Central South University
Yong Liu: Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University
Nu Zhang: Department of Microbiology, Immunology and Molecular Genetics, Long School of Medicine, University of Texas Health Science Center at San Antonio

DOI: https://doi.org/10.1038/s41467-022-33768-x
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 16

Abstract

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TGF-β has been shown to regulate stem-like CD8 + T cell differentiation into tissue resident memory T cells in chronic infection. Here authors show that in tumour-bearing mice, a similar TGF-βdependent CD8 + T cell differentiation program is carried out in the draining lymph nodes, which impedes generation of anti-tumor migratory effector T cells upon future vaccination.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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