Recent Advances in Chronotherapy Targeting Respiratory Diseases

Keshav Raj Paudel; Saurav Kumar Jha; Venkata Sita Rama Raju Allam; Parteek Prasher; Piyush Kumar Gupta; Rahul Bhattacharjee; Niraj Kumar Jha; Sukriti Vishwas; Sachin K. Singh; Jesus Shrestha; Mohammad Imran; Nisha Panth; Dinesh Kumar Chellappan; Majid Ebrahimi Warkiani; Philip M. Hansbro; Kamal Dua

doi:10.3390/pharmaceutics13122008

Pharmaceutics (Nov 2021)

Recent Advances in Chronotherapy Targeting Respiratory Diseases

Keshav Raj Paudel,
Saurav Kumar Jha,
Venkata Sita Rama Raju Allam,
Parteek Prasher,
Piyush Kumar Gupta,
Rahul Bhattacharjee,
Niraj Kumar Jha,
Sukriti Vishwas,
Sachin K. Singh,
Jesus Shrestha,
Mohammad Imran,
Nisha Panth,
Dinesh Kumar Chellappan,
Majid Ebrahimi Warkiani,
Philip M. Hansbro,
Kamal Dua

Affiliations

Keshav Raj Paudel: Centre for Inflammation, Centenary Institute, Sydney, NSW 2050, Australia
Saurav Kumar Jha: Department of Biomedicine, Health and Life Convergence Sciences, BK21 Four, Biomedical and Healthcare Research Institute, Mokpo National University, Muan 58554, Korea
Venkata Sita Rama Raju Allam: Department of Medical Biochemistry and Microbiology, Uppsala University, 75237 Uppsala, Sweden
Parteek Prasher: Department of Chemistry, University of Petroleum & Energy Studies, Dehradun 248007, Uttarakhand, India
Piyush Kumar Gupta: Department of Life Sciences, School of Basic Sciences and Research, Sharda University, Greater Noida 201310, Uttar Pradesh, India
Rahul Bhattacharjee: Kalinga Institute of Industrial Technology (KIIT-DU), KIIT School of Biotechnology, Bhubaneswar 751024, Odisha, India
Niraj Kumar Jha: Department of Biotechnology, School of Engineering & Technology (SET), Sharda University, Plot No. 32-34, Knowledge Park III, Greater Noida 201310, Uttar Pradesh, India
Sukriti Vishwas: School of Pharmaceutical Sciences, Lovely Professional University, Jalandhar-Delhi Grand Trunk Road, Phagwara 144411, Punjab, India
Sachin K. Singh: School of Pharmaceutical Sciences, Lovely Professional University, Jalandhar-Delhi Grand Trunk Road, Phagwara 144411, Punjab, India
Jesus Shrestha: School of Biomedical Engineering, University of Technology Sydney, Sydney, NSW 2007, Australia
Mohammad Imran: Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, Delhi, India
Nisha Panth: Centre for Inflammation, Centenary Institute, Sydney, NSW 2050, Australia
Dinesh Kumar Chellappan: School of Pharmacy, International Medical University, Bukit Jalil, Kuala Lumpur 57000, Malaysia
Majid Ebrahimi Warkiani: School of Biomedical Engineering, University of Technology Sydney, Sydney, NSW 2007, Australia
Philip M. Hansbro: Centre for Inflammation, Centenary Institute, Sydney, NSW 2050, Australia
Kamal Dua: Centre for Inflammation, Centenary Institute, Sydney, NSW 2050, Australia

DOI: https://doi.org/10.3390/pharmaceutics13122008
Journal volume & issue: Vol. 13, no. 12
p. 2008

Abstract

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Respiratory diseases contribute to a significant percentage of mortality and morbidity worldwide. The circadian rhythm is a natural biological process where our bodily functions align with the 24 h oscillation (sleep–wake cycle) process and are controlled by the circadian clock protein/gene. Disruption of the circadian rhythm could alter normal lung function. Chronotherapy is a type of therapy provided at specific time intervals based on an individual’s circadian rhythm. This would allow the drug to show optimum action, and thereby modulate its pharmacokinetics to lessen unwanted or unintended effects. In this review, we deliberated on the recent advances employed in chrono-targeted therapeutics for chronic respiratory diseases.

Published in Pharmaceutics

ISSN: 1999-4923 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine: Pharmacy and materia medica
Website: http://www.mdpi.com/journal/pharmaceutics/

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