Frontiers in Cardiovascular Medicine (Mar 2022)
The Role of Interleukin-6 Family Members in Cardiovascular Diseases
- Yongqi Feng,
- Yongqi Feng,
- Yongqi Feng,
- Di Ye,
- Di Ye,
- Di Ye,
- Zhen Wang,
- Zhen Wang,
- Zhen Wang,
- Heng Pan,
- Heng Pan,
- Heng Pan,
- Xiyi Lu,
- Xiyi Lu,
- Xiyi Lu,
- Menglong Wang,
- Menglong Wang,
- Menglong Wang,
- Yao Xu,
- Yao Xu,
- Yao Xu,
- Junping Yu,
- Junping Yu,
- Junping Yu,
- Jishou Zhang,
- Jishou Zhang,
- Jishou Zhang,
- Mengmeng Zhao,
- Mengmeng Zhao,
- Mengmeng Zhao,
- Shuwan Xu,
- Shuwan Xu,
- Shuwan Xu,
- Wei Pan,
- Wei Pan,
- Wei Pan,
- Zheng Yin,
- Zheng Yin,
- Zheng Yin,
- Jing Ye,
- Jing Ye,
- Jing Ye,
- Jun Wan,
- Jun Wan,
- Jun Wan
Affiliations
- Yongqi Feng
- Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China
- Yongqi Feng
- Cardiovascular Research Institute, Wuhan University, Wuhan, China
- Yongqi Feng
- Hubei Key Laboratory of Cardiology, Wuhan, China
- Di Ye
- Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China
- Di Ye
- Cardiovascular Research Institute, Wuhan University, Wuhan, China
- Di Ye
- Hubei Key Laboratory of Cardiology, Wuhan, China
- Zhen Wang
- Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China
- Zhen Wang
- Cardiovascular Research Institute, Wuhan University, Wuhan, China
- Zhen Wang
- Hubei Key Laboratory of Cardiology, Wuhan, China
- Heng Pan
- Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China
- Heng Pan
- Cardiovascular Research Institute, Wuhan University, Wuhan, China
- Heng Pan
- Hubei Key Laboratory of Cardiology, Wuhan, China
- Xiyi Lu
- Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China
- Xiyi Lu
- Cardiovascular Research Institute, Wuhan University, Wuhan, China
- Xiyi Lu
- Hubei Key Laboratory of Cardiology, Wuhan, China
- Menglong Wang
- Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China
- Menglong Wang
- Cardiovascular Research Institute, Wuhan University, Wuhan, China
- Menglong Wang
- Hubei Key Laboratory of Cardiology, Wuhan, China
- Yao Xu
- Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China
- Yao Xu
- Cardiovascular Research Institute, Wuhan University, Wuhan, China
- Yao Xu
- Hubei Key Laboratory of Cardiology, Wuhan, China
- Junping Yu
- Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China
- Junping Yu
- Cardiovascular Research Institute, Wuhan University, Wuhan, China
- Junping Yu
- Hubei Key Laboratory of Cardiology, Wuhan, China
- Jishou Zhang
- Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China
- Jishou Zhang
- Cardiovascular Research Institute, Wuhan University, Wuhan, China
- Jishou Zhang
- Hubei Key Laboratory of Cardiology, Wuhan, China
- Mengmeng Zhao
- Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China
- Mengmeng Zhao
- Cardiovascular Research Institute, Wuhan University, Wuhan, China
- Mengmeng Zhao
- Hubei Key Laboratory of Cardiology, Wuhan, China
- Shuwan Xu
- Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China
- Shuwan Xu
- Cardiovascular Research Institute, Wuhan University, Wuhan, China
- Shuwan Xu
- Hubei Key Laboratory of Cardiology, Wuhan, China
- Wei Pan
- Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China
- Wei Pan
- Cardiovascular Research Institute, Wuhan University, Wuhan, China
- Wei Pan
- Hubei Key Laboratory of Cardiology, Wuhan, China
- Zheng Yin
- Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China
- Zheng Yin
- Cardiovascular Research Institute, Wuhan University, Wuhan, China
- Zheng Yin
- Hubei Key Laboratory of Cardiology, Wuhan, China
- Jing Ye
- Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China
- Jing Ye
- Cardiovascular Research Institute, Wuhan University, Wuhan, China
- Jing Ye
- Hubei Key Laboratory of Cardiology, Wuhan, China
- Jun Wan
- Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China
- Jun Wan
- Cardiovascular Research Institute, Wuhan University, Wuhan, China
- Jun Wan
- Hubei Key Laboratory of Cardiology, Wuhan, China
- DOI
- https://doi.org/10.3389/fcvm.2022.818890
- Journal volume & issue
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Vol. 9
Abstract
Cardiovascular disease is one of the main causes of human mortality. Cytokines play crucial roles in the development of cardiovascular disease. Interleukin (IL)-6 family members are a series of cytokines, including IL-6, IL-11, IL-30, IL-31, OSM, LIF, CNTF, CT-1, CT-2, and CLC, that regulate multiple biological effects. Experimental and clinical evidence shows that IL-6 family members are closely related to cardiovascular diseases such as atherosclerosis, hypertension, aortic dissection, cardiac fibrosis, and cardiomyopathy. This review mainly discusses the role of IL-6 family members in cardiovascular disease for the sake of identifying possible intervention targets for cardiovascular disease prevention and treatment.
Keywords
- cardiovascular diseases
- IL-6 family cytokines
- atherosclerosis
- coronary artery disease
- cardiac remodeling
