Annals of Clinical and Translational Neurology (Jul 2019)

1H‐31P magnetic resonance spectroscopy: effect of biotin in multiple sclerosis

  • Carole Guillevin,
  • Pierre Agius,
  • Mathieu Naudin,
  • Guillaume Herpe,
  • Stéphanie Ragot,
  • Nicolas Maubeuge,
  • Jean Philippe Neau,
  • Rémy Guillevin

DOI
https://doi.org/10.1002/acn3.50825
Journal volume & issue
Vol. 6, no. 7
pp. 1332 – 1337

Abstract

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Abstract Biotin is thought to improve functional impairment in progressive multiple sclerosis (MS) by upregulating bioenergetic metabolism. We enrolled 19 patients suffering from progressive MS (5 primary and 14 secondary Progressive‐MS). Using cerebral multinuclear magnetic resonance spectroscopy (MMRS) and clinical evaluation before and after 6 months of biotin cure, we showed significant modifications of: PME/PDE, ATP, and lactate resonances; an improvement of EDSS Neuroscore. Our results are consistent with metabolic pathways concerned with biotin action and could suggest the usefulness of MMRS for monitoring.