Nature Communications (Jul 2022)
Mechanism of threonine ADP-ribosylation of F-actin by a Tc toxin
Abstract
Entomopathogenic bacteria used for pest control secrete potent Tc toxins. Here, the authors combine biochemistry, solution and solid-state NMR spectroscopy and cryo-EM to show in atomic detail how the toxin disrupts the host cell cytoskeleton and kills the target cell.