A Green Synthesis and Antibacterial Activity of N-Arylsulfonylhydrazone Compounds

Abstract

A green method has been developed for the synthesis of N-arylsulfonylhydrazones via a simple grindstone procedure. By grinding mixtures of benzensulfonyl hydrazides and a series of aryl aldehydes or ketones in the mortar using L-tyrosine as catalyst, 24 N-arylsulfonylhydrazones were synthesized in a few minutes with high yield. All compounds were screened for their antibacterial activities. Most of them exhibit some antibacterial activities especially for 3d, 3l and 3v showing high activity against Staphylococcus aureus and Escherichia coli.

Keywords

• solvent-free
• n-arylsulfonylhydrazone
• l-tyrosine
• grindstone method
• antibacterial activities