Frontiers in Aging Neuroscience (Jul 2024)

Occlusion dysfunction and Alzheimer’s disease: Mendelian randomization study

  • Qing Wang,
  • Wenyu Zhen,
  • Rui Hu,
  • Zifei Wang,
  • Yuqiang Sun,
  • Wansu Sun,
  • Chunxia Huang,
  • Jianguang Xu,
  • Hengguo Zhang

DOI
https://doi.org/10.3389/fnagi.2024.1423322
Journal volume & issue
Vol. 16

Abstract

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AimOcclusion dysfunction (OD) is increasingly linked to Alzheimer’s disease (AD). This study aimed to elucidate the causal relationship between OD and AD using Mendelian randomization (MR) analysis.Materials and methodsGenome-wide association study (GWAS) meta-analysis data obtained from FinnGen, IEU Open GWAS, and UK Biobank (UKBB) was represented as instrumental variables. We validated the causal relationship between periodontal disease (PD), loose teeth (PD & occlusion dysfunction), dentures restoration (occlusion recovery), and AD.ResultsAccording to the MR analysis, PD and AD have no direct causal relationship (P = 0.395, IVW). However, loose teeth significantly increased the risk of AD progression (P = 0.017, IVW, OR = 187.3567, 95%CI = 2.54E+00−1.38E+04). These findings were further supported by the negative causal relationship between dentures restoration and AD (P = 0.015, IVW, OR = 0.0234, 95%CI = 1.13E-03−0.485).ConclusionThe occlusion dysfunction can ultimately induce Alzheimer’s disease. Occlusion function was a potentially protective factor for maintaining neurological health.

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