Enhanced mitochondrial biogenesis promotes neuroprotection in human pluripotent stem cell derived retinal ganglion cells

Michelle Surma; Kavitha Anbarasu; Sayanta Dutta; Leonardo J. Olivera Perez; Kang-Chieh Huang; Jason S. Meyer; Arupratan Das

doi:10.1038/s42003-023-04576-w

Communications Biology (Feb 2023)

Enhanced mitochondrial biogenesis promotes neuroprotection in human pluripotent stem cell derived retinal ganglion cells

Michelle Surma,
Kavitha Anbarasu,
Sayanta Dutta,
Leonardo J. Olivera Perez,
Kang-Chieh Huang,
Jason S. Meyer,
Arupratan Das

Affiliations

Michelle Surma: Department of Ophthalmology, Eugene and Marilyn Glick Eye Institute, Indiana University
Kavitha Anbarasu: Department of Ophthalmology, Eugene and Marilyn Glick Eye Institute, Indiana University
Sayanta Dutta: Department of Ophthalmology, Eugene and Marilyn Glick Eye Institute, Indiana University
Leonardo J. Olivera Perez: Indiana University School of Medicine
Kang-Chieh Huang: Department of Biology, Indiana University Purdue University
Jason S. Meyer: Department of Ophthalmology, Eugene and Marilyn Glick Eye Institute, Indiana University
Arupratan Das: Department of Ophthalmology, Eugene and Marilyn Glick Eye Institute, Indiana University

DOI: https://doi.org/10.1038/s42003-023-04576-w
Journal volume & issue: Vol. 6, no. 1
pp. 1 – 13

Abstract

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Human retinal ganglion cells generate mitochondria under mitochondrial damage conditions, with TBK1 inhibition activating mitochondrial biogenesis and neuroprotective effects in both WT and glaucomatous RGC neurons.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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