Metformin mitigates osteoarthritis progression by modulating the PI3K/AKT/mTOR signaling pathway and enhancing chondrocyte autophagy

• Xu Tianjie,
• Liu Kainan,
• Fan Jiaxin,
• Jia Xiang,
• Guo Xiaoling,
• Zhao Xingwang,
• Cao Yanhua,
• Zhang Hui,
• Wang Qian

Affiliations

Xu Tianjie

School of Basic Medical Sciences, North China University of Science and Technology, Tangshan, Hebei, 063000, China

Liu Kainan

Department of Basic Medicine, Xingtai Medical College, Xingtai, Hebei, 054000, China

Fan Jiaxin

School of Basic Medical Sciences, North China University of Science and Technology, Tangshan, Hebei, 063000, China

Jia Xiang

School of Basic Medical Sciences, North China University of Science and Technology, Tangshan, Hebei, 063000, China

Guo Xiaoling

School of Basic Medical Sciences, North China University of Science and Technology, Tangshan, Hebei, 063000, China

Zhao Xingwang

Department of Orthopedics, Affiliated Hospital of North China University of Science and Technology, Tangshan, Hebei, 063000, China

Cao Yanhua

School of Public Health, North China University of Science and Technology, Tangshan, Hebei, 063000, China

Zhang Hui

Department of Joint Surgery 1, The Second Hospital of Tangshan, Tangshan, Hebei, 063000, China

Wang Qian

School of Basic Medical Sciences, North China University of Science and Technology, Tangshan, Hebei, 063000, China