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Open Life Sciences
(Jul 2024)
Metformin mitigates osteoarthritis progression by modulating the PI3K/AKT/mTOR signaling pathway and enhancing chondrocyte autophagy
Xu Tianjie,
Liu Kainan,
Fan Jiaxin,
Jia Xiang,
Guo Xiaoling,
Zhao Xingwang,
Cao Yanhua,
Zhang Hui,
Wang Qian
Affiliations
Xu Tianjie
School of Basic Medical Sciences, North China University of Science and Technology, Tangshan, Hebei, 063000, China
Liu Kainan
Department of Basic Medicine, Xingtai Medical College, Xingtai, Hebei, 054000, China
Fan Jiaxin
School of Basic Medical Sciences, North China University of Science and Technology, Tangshan, Hebei, 063000, China
Jia Xiang
School of Basic Medical Sciences, North China University of Science and Technology, Tangshan, Hebei, 063000, China
Guo Xiaoling
School of Basic Medical Sciences, North China University of Science and Technology, Tangshan, Hebei, 063000, China
Zhao Xingwang
Department of Orthopedics, Affiliated Hospital of North China University of Science and Technology, Tangshan, Hebei, 063000, China
Cao Yanhua
School of Public Health, North China University of Science and Technology, Tangshan, Hebei, 063000, China
Zhang Hui
Department of Joint Surgery 1, The Second Hospital of Tangshan, Tangshan, Hebei, 063000, China
Wang Qian
School of Basic Medical Sciences, North China University of Science and Technology, Tangshan, Hebei, 063000, China
DOI
https://doi.org/10.1515/biol-2022-0922
Journal volume & issue
Vol. 19, no. 1
pp. 645842 – 83
Abstract
Read online
No abstracts available.
Keywords
met
osteoarthritis
autophagy
cartilage
pi3k/akt/mtor
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