Nature Communications (Aug 2019)

Blood stem cell-forming haemogenic endothelium in zebrafish derives from arterial endothelium

  • Florian Bonkhofer,
  • Rossella Rispoli,
  • Philip Pinheiro,
  • Monika Krecsmarik,
  • Janina Schneider-Swales,
  • Ingrid Ho Ching Tsang,
  • Marella de Bruijn,
  • Rui Monteiro,
  • Tessa Peterkin,
  • Roger Patient

DOI
https://doi.org/10.1038/s41467-019-11423-2
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 14

Abstract

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HSCs emerge from haemogenic endothelium (HE) in the dorsal aorta but whether these tissues share a common lineage is unclear. Here, the authors use a zebrafish runx1 reporter to show that HE maintains an arterial gene expression profile in the absence of Runx1, suggesting the aortic endothelium as a precursor of HE.