Hypoxia-Inducible Factor 1α (HIF1α) Suppresses Virus Replication in Human Cytomegalovirus Infection by Limiting Kynurenine Synthesis

Lisa M. Wise; Yuecheng Xi; John G. Purdy

doi:10.1128/mBio.02956-20

mBio (Apr 2021)

Hypoxia-Inducible Factor 1α (HIF1α) Suppresses Virus Replication in Human Cytomegalovirus Infection by Limiting Kynurenine Synthesis

Lisa M. Wise,
Yuecheng Xi,
John G. Purdy

Affiliations

Lisa M. Wise: Department of Immunobiology, University of Arizona, Tucson, Arizona, USA
Yuecheng Xi: BIO5 Institute, University of Arizona Tucson, Tucson, Arizona, USA
John G. Purdy: ORCiD; Department of Immunobiology, University of Arizona, Tucson, Arizona, USA

DOI: https://doi.org/10.1128/mBio.02956-20
Journal volume & issue: Vol. 12, no. 2

Abstract

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Viruses, including human cytomegalovirus (HCMV), reprogram cellular metabolism using host metabolic regulators to support virus replication. Alternatively, in response to infection, the host can use metabolism to limit virus replication.

Published in mBio

ISSN: 2161-2129 (Print); 2150-7511 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/mbio

About the journal