Electron microscopic study of skeletal muscle in the Lambert–Eaton myasthenic syndrome

Abstract

Skeletal muscle biopsies of 7 patients with Lambert–Eaton syndrome were studied. Revealed that specific changes in the neuromuscular junctions are the complication of the postsynaptic region organization. Along with this, there is a destructive process in axon terminals, which may be terminated by the denervation of muscle fibers. Violations of the structure of muscle fibers were observed. A new hypothesis of the Lambert–Eaton syndrome pathogenesis was preposed.

Keywords

• lambert–eaton myasthenic syndrome
• ultrastructure
• neuro-muscular junction
• skeletal muscle
• pathogenesis