Nature Communications (May 2017)
Acquired IFNγ resistance impairs anti-tumor immunity and gives rise to T-cell-resistant melanoma lesions
- Antje Sucker,
- Fang Zhao,
- Natalia Pieper,
- Christina Heeke,
- Raffaela Maltaner,
- Nadine Stadtler,
- Birgit Real,
- Nicola Bielefeld,
- Sebastian Howe,
- Benjamin Weide,
- Ralf Gutzmer,
- Jochen Utikal,
- Carmen Loquai,
- Helen Gogas,
- Ludger Klein-Hitpass,
- Michael Zeschnigk,
- Astrid M. Westendorf,
- Mirko Trilling,
- Susanne Horn,
- Bastian Schilling,
- Dirk Schadendorf,
- Klaus G. Griewank,
- Annette Paschen
Affiliations
- Antje Sucker
- Department of Dermatology, University Hospital Essen, University Duisburg-Essen
- Fang Zhao
- Department of Dermatology, University Hospital Essen, University Duisburg-Essen
- Natalia Pieper
- Department of Dermatology, University Hospital Essen, University Duisburg-Essen
- Christina Heeke
- Department of Dermatology, University Hospital Essen, University Duisburg-Essen
- Raffaela Maltaner
- Department of Dermatology, University Hospital Essen, University Duisburg-Essen
- Nadine Stadtler
- Department of Dermatology, University Hospital Essen, University Duisburg-Essen
- Birgit Real
- Department of Dermatology, University Hospital Essen, University Duisburg-Essen
- Nicola Bielefeld
- Department of Dermatology, University Hospital Essen, University Duisburg-Essen
- Sebastian Howe
- Institute of Virology, University Hospital Essen, University Duisburg-Essen
- Benjamin Weide
- Division of Dermatooncology, Department of Dermatology, University Medical Center Tübingen
- Ralf Gutzmer
- Department of Dermatology and Allergy, Skin Cancer Center Hannover, Hannover Medical School
- Jochen Utikal
- Department of Dermatology, German Cancer Research Center (DKFZ), Skin Cancer Unit, Heidelberg and University Medical Center Mannheim, Venereology and Allergology, Ruprecht-Karl University of Heidelberg
- Carmen Loquai
- Department of Dermatology, Skin Cancer Center, University of Mainz Medical Center
- Helen Gogas
- First Department of Medicine,National and Kapodistrian University of Athens
- Ludger Klein-Hitpass
- Institute of Cell Biology, University Hospital Essen, University of Duisburg-Essen
- Michael Zeschnigk
- Institute of Human Genetics, University Hospital Essen, University Duisburg-Essen, West German Cancer Center and the German Cancer Consortium (DKTK)
- Astrid M. Westendorf
- Institute of Medical Microbiology, University Hospital Essen, University of Duisburg-Essen
- Mirko Trilling
- Institute of Virology, University Hospital Essen, University Duisburg-Essen
- Susanne Horn
- Department of Dermatology, University Hospital Essen, University Duisburg-Essen
- Bastian Schilling
- Department of Dermatology, University Hospital Essen, University Duisburg-Essen
- Dirk Schadendorf
- Department of Dermatology, University Hospital Essen, University Duisburg-Essen
- Klaus G. Griewank
- Department of Dermatology, University Hospital Essen, University Duisburg-Essen
- Annette Paschen
- Department of Dermatology, University Hospital Essen, University Duisburg-Essen
- DOI
- https://doi.org/10.1038/ncomms15440
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 15
Abstract
IFNγ secretion by CD8+T cells is critical for immunotherapy efficacy. In this study, the authors show that melanoma patients can become resistant to immunotherapy by acquiring chromosomal alterations and subsequent inactivating mutations in genes of the IFNγ signalling cascade, most often JAK1 or JAK2.
