Nature Communications (May 2021)
Yap regulates skeletal muscle fatty acid oxidation and adiposity in metabolic disease
- K. I. Watt,
- D. C. Henstridge,
- M. Ziemann,
- C. B. Sim,
- M. K. Montgomery,
- D. Samocha-Bonet,
- B. L. Parker,
- G. T. Dodd,
- S. T. Bond,
- T. M. Salmi,
- R. S. Lee,
- R. E. Thomson,
- A. Hagg,
- J. R. Davey,
- H. Qian,
- R. Koopman,
- A. El-Osta,
- J. R. Greenfield,
- M. J. Watt,
- M. A. Febbraio,
- B. G. Drew,
- A. G. Cox,
- E. R. Porrello,
- K. F. Harvey,
- P. Gregorevic
Affiliations
- K. I. Watt
- Centre for Muscle Research, The University of Melbourne
- D. C. Henstridge
- School of Health Sciences, University of Tasmania
- M. Ziemann
- Deakin University
- C. B. Sim
- Murdoch Children’s Research Institute
- M. K. Montgomery
- Dept of Physiology, The University of Melbourne
- D. Samocha-Bonet
- Division of Healthy Aging, Garvan Institute of Medical Research
- B. L. Parker
- Centre for Muscle Research, The University of Melbourne
- G. T. Dodd
- Dept of Physiology, The University of Melbourne
- S. T. Bond
- Baker Heart and Diabetes Institute
- T. M. Salmi
- Peter MacCallum Cancer Centre
- R. S. Lee
- Metabolic Disease and Obesity Phenotyping Facility, Monash University
- R. E. Thomson
- Centre for Muscle Research, The University of Melbourne
- A. Hagg
- Centre for Muscle Research, The University of Melbourne
- J. R. Davey
- Centre for Muscle Research, The University of Melbourne
- H. Qian
- Centre for Muscle Research, The University of Melbourne
- R. Koopman
- Centre for Muscle Research, The University of Melbourne
- A. El-Osta
- Dept of Diabetes, Central Clinical School, Monash University
- J. R. Greenfield
- Division of Healthy Aging, Garvan Institute of Medical Research
- M. J. Watt
- Dept of Physiology, The University of Melbourne
- M. A. Febbraio
- Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University
- B. G. Drew
- Baker Heart and Diabetes Institute
- A. G. Cox
- Peter MacCallum Cancer Centre
- E. R. Porrello
- Dept of Physiology, The University of Melbourne
- K. F. Harvey
- Peter MacCallum Cancer Centre
- P. Gregorevic
- Centre for Muscle Research, The University of Melbourne
- DOI
- https://doi.org/10.1038/s41467-021-23240-7
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 14
Abstract
The mechanisms driving metabolic dysfunction in obesity remain incompletely understood. Here, the authors show that the levels of Hippo pathway effector YAP are reduced in muscle from individuals with insulin resistance and obese-diabetic mice, and that YAP promotes skeletal muscle lipid metabolism and limits adiposity in obese mice.
