Nature Communications (Aug 2021)
Amnion signals are essential for mesoderm formation in primates
- Ran Yang,
- Alexander Goedel,
- Yu Kang,
- Chenyang Si,
- Chu Chu,
- Yi Zheng,
- Zhenzhen Chen,
- Peter J. Gruber,
- Yao Xiao,
- Chikai Zhou,
- Nevin Witman,
- Elif Eroglu,
- Chuen-Yan Leung,
- Yongchang Chen,
- Jianping Fu,
- Weizhi Ji,
- Fredrik Lanner,
- Yuyu Niu,
- Kenneth R. Chien
Affiliations
- Ran Yang
- Department of Cell and Molecular Biology, Karolinska Institutet
- Alexander Goedel
- Department of Cell and Molecular Biology, Karolinska Institutet
- Yu Kang
- Yunnan Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology
- Chenyang Si
- Yunnan Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology
- Chu Chu
- Yunnan Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology
- Yi Zheng
- Department of Mechanical Engineering, University of Michigan
- Zhenzhen Chen
- Yunnan Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology
- Peter J. Gruber
- Department of Cell and Molecular Biology, Karolinska Institutet
- Yao Xiao
- Department of Cell and Molecular Biology, Karolinska Institutet
- Chikai Zhou
- Department of Cell and Molecular Biology, Karolinska Institutet
- Nevin Witman
- Department of Cell and Molecular Biology, Karolinska Institutet
- Elif Eroglu
- Department of Cell and Molecular Biology, Karolinska Institutet
- Chuen-Yan Leung
- Department of Cell and Molecular Biology, Karolinska Institutet
- Yongchang Chen
- Yunnan Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology
- Jianping Fu
- Department of Mechanical Engineering, University of Michigan
- Weizhi Ji
- Yunnan Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology
- Fredrik Lanner
- Department of Clinical Sciences, Intervention and Technology, Karolinska Institutet
- Yuyu Niu
- Yunnan Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology
- Kenneth R. Chien
- Department of Cell and Molecular Biology, Karolinska Institutet
- DOI
- https://doi.org/10.1038/s41467-021-25186-2
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 14
Abstract
Human and murine embryonic development has disparities, highlighting the need for primate systems. Here, the authors construct a post-implantation transcriptional atlas from non-human primate embryos and show ISL1 controls a gene regulatory network in the amnion required for mesoderm formation.
