Nature Communications (Mar 2020)

Autophagy-dependent filopodial kinetics restrict synaptic partner choice during Drosophila brain wiring

  • Ferdi Ridvan Kiral,
  • Gerit Arne Linneweber,
  • Thomas Mathejczyk,
  • Svilen Veselinov Georgiev,
  • Mathias F. Wernet,
  • Bassem A. Hassan,
  • Max von Kleist,
  • Peter Robin Hiesinger

DOI
https://doi.org/10.1038/s41467-020-14781-4
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 14

Abstract

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The molecular mechanisms that restrict synapse formation with incorrect partners remain unclear. Here, authors use 4D imaging in developing Drosophila brains to show that filopodial kinetics are regulated by autophagy and this restricts inappropriate partner choice through a process of kinetic exclusion