Structural Basis of Ligand Selectivity by a Bacterial Adhesin Lectin Involved in Multispecies Biofilm Formation

Shuaiqi Guo; Tyler D. R. Vance; Hossein Zahiri; Robert Eves; Corey Stevens; Jan-Hendrik Hehemann; Silvia Vidal-Melgosa; Peter L. Davies

doi:10.1128/mBio.00130-21

mBio (Apr 2021)

Structural Basis of Ligand Selectivity by a Bacterial Adhesin Lectin Involved in Multispecies Biofilm Formation

Shuaiqi Guo,
Tyler D. R. Vance,
Hossein Zahiri,
Robert Eves,
Corey Stevens,
Jan-Hendrik Hehemann,
Silvia Vidal-Melgosa,
Peter L. Davies

Affiliations

Shuaiqi Guo: Department of Biomedical and Molecular Sciences, Queen’s University, Kingston, Ontario, Canada
Tyler D. R. Vance: Department of Biomedical and Molecular Sciences, Queen’s University, Kingston, Ontario, Canada
Hossein Zahiri: Department of Biomedical and Molecular Sciences, Queen’s University, Kingston, Ontario, Canada
Robert Eves: Department of Biomedical and Molecular Sciences, Queen’s University, Kingston, Ontario, Canada
Corey Stevens: Department of Biomedical and Molecular Sciences, Queen’s University, Kingston, Ontario, Canada
Jan-Hendrik Hehemann: Max Planck Institute for Marine Microbiology, Bremen, Germany
Silvia Vidal-Melgosa: Max Planck Institute for Marine Microbiology, Bremen, Germany
Peter L. Davies: ORCiD; Department of Biomedical and Molecular Sciences, Queen’s University, Kingston, Ontario, Canada

DOI: https://doi.org/10.1128/mBio.00130-21
Journal volume & issue: Vol. 12, no. 2

Abstract

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Bacterial adhesins are key virulence factors that are essential for the pathogen-host interaction and biofilm formation that cause most infections. Many of the adhesin-driven cell-cell interactions are mediated by lectins.

Published in mBio

ISSN: 2161-2129 (Print); 2150-7511 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/mbio

About the journal