Hexosamine biosynthetic pathway and O-GlcNAc-processing enzymes regulate daily rhythms in protein O-GlcNAcylation

Xianhui Liu; Ivana Blaženović; Adam J. Contreras; Thu M. Pham; Christine A. Tabuloc; Ying H. Li; Jian Ji; Oliver Fiehn; Joanna C. Chiu

doi:10.1038/s41467-021-24301-7

Nature Communications (Jul 2021)

Hexosamine biosynthetic pathway and O-GlcNAc-processing enzymes regulate daily rhythms in protein O-GlcNAcylation

Xianhui Liu,
Ivana Blaženović,
Adam J. Contreras,
Thu M. Pham,
Christine A. Tabuloc,
Ying H. Li,
Jian Ji,
Oliver Fiehn,
Joanna C. Chiu

Affiliations

Xianhui Liu: Department of Entomology and Nematology, College of Agricultural and Environmental Sciences, University of California
Ivana Blaženović: West Coast Metabolomics Center, University of California
Adam J. Contreras: Department of Entomology and Nematology, College of Agricultural and Environmental Sciences, University of California
Thu M. Pham: Department of Entomology and Nematology, College of Agricultural and Environmental Sciences, University of California
Christine A. Tabuloc: Department of Entomology and Nematology, College of Agricultural and Environmental Sciences, University of California
Ying H. Li: Department of Entomology and Nematology, College of Agricultural and Environmental Sciences, University of California
Jian Ji: School of Food Science, State Key Laboratory of Food Science and Technology, National Engineering Research Center for Functional Foods, School of Food Science Synergetic Innovation Center of Food Safety and Nutrition, Jiangnan University
Oliver Fiehn: West Coast Metabolomics Center, University of California
Joanna C. Chiu: Department of Entomology and Nematology, College of Agricultural and Environmental Sciences, University of California

DOI: https://doi.org/10.1038/s41467-021-24301-7
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 16

Abstract

Read online

Misalignment between lifestyle and the natural day-night cycle, such as mistimed eating, can negatively impact health. Here the authors show that mistimed feeding alters protein O-GlcNAcylation, a nutrient sensitive post-translational modification.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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