Frontiers in Medicine (Jun 2021)
Major Characteristics of Severity and Mortality in Diabetic Patients With COVID-19 and Establishment of Severity Risk Score
- Yu-Feng Xiao,
- Jia-Lin He,
- Jia-Lin He,
- Jia-Lin He,
- Yu Xu,
- Yu Xu,
- Yu Xu,
- Xi Liu,
- Xi Liu,
- Xi Liu,
- Hui Lin,
- Qi Li,
- Qi Li,
- Qi Li,
- Zhi Xu,
- Zhi Xu,
- Zhi Xu,
- Ming-Dong Hu,
- Ming-Dong Hu,
- Ming-Dong Hu,
- Xiao-Bao Ren,
- Xiao-Bao Ren,
- Xiao-Bao Ren,
- Cheng Zhang,
- Cheng Zhang,
- Cheng Zhang,
- Wen-Jing Zhang,
- Wen-Jing Zhang,
- Wen-Jing Zhang,
- Wei Duan,
- Wei Duan,
- Wei Duan,
- Yong-Feng Tian,
- Yong-Feng Tian,
- Yong-Feng Tian,
- Ping Li,
- Ping Li,
- Ping Li,
- Hao Wu,
- Hao Wu,
- Cai-Ping Song,
- Cai-Ping Song,
- Cai-Ping Song,
- En Liu,
- Shi-Ming Yang,
- Shi-Ming Yang,
- Shi-Ming Yang
Affiliations
- Yu-Feng Xiao
- Department of Gastroenterology, Xinqiao Hospital, The Army Medical University, Chongqing, China
- Jia-Lin He
- Department of Gastroenterology, Xinqiao Hospital, The Army Medical University, Chongqing, China
- Jia-Lin He
- Huo-Shen-Shan Hospital, Wuhan, China
- Jia-Lin He
- The Medical Team of the Army Medical University, Jin-Yin-Tan Hospital, Wuhan, China
- Yu Xu
- Huo-Shen-Shan Hospital, Wuhan, China
- Yu Xu
- The Medical Team of the Army Medical University, Jin-Yin-Tan Hospital, Wuhan, China
- Yu Xu
- Department of Respiratory and Critical Care Medicine, Xinqiao Hospital, The Army Medical University, Chongqing, China
- Xi Liu
- Department of Gastroenterology, Xinqiao Hospital, The Army Medical University, Chongqing, China
- Xi Liu
- The Medical Team of the Army Medical University, Jin-Yin-Tan Hospital, Wuhan, China
- Xi Liu
- Taikang Tongji Hospital, Wuhan, China
- Hui Lin
- Department of Gastroenterology, Xinqiao Hospital, The Army Medical University, Chongqing, China
- Qi Li
- Huo-Shen-Shan Hospital, Wuhan, China
- Qi Li
- The Medical Team of the Army Medical University, Jin-Yin-Tan Hospital, Wuhan, China
- Qi Li
- Department of Respiratory and Critical Care Medicine, Xinqiao Hospital, The Army Medical University, Chongqing, China
- Zhi Xu
- Huo-Shen-Shan Hospital, Wuhan, China
- Zhi Xu
- Department of Respiratory and Critical Care Medicine, Xinqiao Hospital, The Army Medical University, Chongqing, China
- Zhi Xu
- Taikang Tongji Hospital, Wuhan, China
- Ming-Dong Hu
- Huo-Shen-Shan Hospital, Wuhan, China
- Ming-Dong Hu
- The Medical Team of the Army Medical University, Jin-Yin-Tan Hospital, Wuhan, China
- Ming-Dong Hu
- Department of Respiratory and Critical Care Medicine, Xinqiao Hospital, The Army Medical University, Chongqing, China
- Xiao-Bao Ren
- Huo-Shen-Shan Hospital, Wuhan, China
- Xiao-Bao Ren
- The Medical Team of the Army Medical University, Jin-Yin-Tan Hospital, Wuhan, China
- Xiao-Bao Ren
- Department of Emergency, Xinan Hospital, The Army Medical University, Chongqing, China
- Cheng Zhang
- Huo-Shen-Shan Hospital, Wuhan, China
- Cheng Zhang
- The Medical Team of the Army Medical University, Jin-Yin-Tan Hospital, Wuhan, China
- Cheng Zhang
- Department of Hematology, Xinqiao Hospital, The Army Medical University, Chongqing, China
- Wen-Jing Zhang
- Huo-Shen-Shan Hospital, Wuhan, China
- Wen-Jing Zhang
- The Medical Team of the Army Medical University, Jin-Yin-Tan Hospital, Wuhan, China
- Wen-Jing Zhang
- Department of Respiratory and Critical Care Medicine, Xinqiao Hospital, The Army Medical University, Chongqing, China
- Wei Duan
- Huo-Shen-Shan Hospital, Wuhan, China
- Wei Duan
- The Medical Team of the Army Medical University, Jin-Yin-Tan Hospital, Wuhan, China
- Wei Duan
- Department of Neurology, Xinqiao Hospital, The Army Medical University, Chongqing, China
- Yong-Feng Tian
- Huo-Shen-Shan Hospital, Wuhan, China
- Yong-Feng Tian
- The Medical Team of the Army Medical University, Jin-Yin-Tan Hospital, Wuhan, China
- Yong-Feng Tian
- Department of Endocrinology, Xinqiao Hospital, The Army Medical University, Chongqing, China
- Ping Li
- Huo-Shen-Shan Hospital, Wuhan, China
- Ping Li
- The Medical Team of the Army Medical University, Jin-Yin-Tan Hospital, Wuhan, China
- Ping Li
- 0Department of Cardiology, Xinqiao Hospital, The Army Medical University, Chongqing, China
- Hao Wu
- Taikang Tongji Hospital, Wuhan, China
- Hao Wu
- 1Xinqiao Hospital, The Army Medical University, Chongqing, China
- Cai-Ping Song
- Huo-Shen-Shan Hospital, Wuhan, China
- Cai-Ping Song
- The Medical Team of the Army Medical University, Jin-Yin-Tan Hospital, Wuhan, China
- Cai-Ping Song
- 1Xinqiao Hospital, The Army Medical University, Chongqing, China
- En Liu
- Department of Gastroenterology, Xinqiao Hospital, The Army Medical University, Chongqing, China
- Shi-Ming Yang
- Department of Gastroenterology, Xinqiao Hospital, The Army Medical University, Chongqing, China
- Shi-Ming Yang
- Huo-Shen-Shan Hospital, Wuhan, China
- Shi-Ming Yang
- The Medical Team of the Army Medical University, Jin-Yin-Tan Hospital, Wuhan, China
- DOI
- https://doi.org/10.3389/fmed.2021.655604
- Journal volume & issue
-
Vol. 8
Abstract
Objectives: Diabetes is a risk factor for poor COVID-19 prognosis. The analysis of related prognostic factors in diabetic patients with COVID-19 would be helpful for further treatment of such patients.Methods: This retrospective study involved 3623 patients with COVID-19 (325 with diabetes). Clinical characteristics and laboratory tests were collected and compared between the diabetic group and the non-diabetic group. Binary logistic regression analysis was applied to explore risk factors associated in diabetic patients with COVID-19. A prediction model was built based on these risk factors.Results: The risk factors for higher mortality in diabetic patients with COVID-19 were dyspnea, lung disease, cardiovascular diseases, neutrophil, PLT count, and CKMB. Similarly, dyspnea, cardiovascular diseases, neutrophil, PLT count, and CKMB were risk factors related to the severity of diabetes with COVID-19. Based on these factors, a risk score was built to predict the severity of disease in diabetic patients with COVID-19. Patients with a score of 7 or higher had an odds ratio of 7.616.Conclusions: Dyspnea is a critical clinical manifestation that is closely related to the severity of disease in diabetic patients with COVID-19. Attention should also be paid to the neutrophil, PLT count and CKMB levels after admission.
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