Nature Communications (Nov 2018)

CDC20B is required for deuterosome-mediated centriole production in multiciliated cells

  • Diego R. Revinski,
  • Laure-Emmanuelle Zaragosi,
  • Camille Boutin,
  • Sandra Ruiz-Garcia,
  • Marie Deprez,
  • Virginie Thomé,
  • Olivier Rosnet,
  • Anne-Sophie Gay,
  • Olivier Mercey,
  • Agnès Paquet,
  • Nicolas Pons,
  • Gilles Ponzio,
  • Brice Marcet,
  • Laurent Kodjabachian,
  • Pascal Barbry

DOI
https://doi.org/10.1038/s41467-018-06768-z
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 15

Abstract

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In vertebrate multiciliated cells, most centrioles are synthesized and released by poorly characterized structures called deuterosomes. Here, the authors report that the previously-uncharacterized Cdc20b in mouse and Xenopus associates with deuterosomes and contributes to centriole release.