Nature Communications (Aug 2016)
Graft-infiltrating host dendritic cells play a key role in organ transplant rejection
- Quan Zhuang,
- Quan Liu,
- Sherrie J. Divito,
- Qiang Zeng,
- Karim M. Yatim,
- Andrew D. Hughes,
- Darling M. Rojas-Canales,
- A. Nakao,
- William J. Shufesky,
- Amanda L. Williams,
- Rishab Humar,
- Rosemary A. Hoffman,
- Warren D. Shlomchik,
- Martin H. Oberbarnscheidt,
- Fadi G. Lakkis,
- Adrian E. Morelli
Affiliations
- Quan Zhuang
- Department of Surgery, Thomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine
- Quan Liu
- Department of Surgery, Thomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine
- Sherrie J. Divito
- Department of Surgery, Thomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine
- Qiang Zeng
- Department of Surgery, Thomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine
- Karim M. Yatim
- Department of Surgery, Thomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine
- Andrew D. Hughes
- Department of Surgery, Thomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine
- Darling M. Rojas-Canales
- Department of Surgery, Thomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine
- A. Nakao
- Department of Surgery, Thomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine
- William J. Shufesky
- Department of Surgery, Thomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine
- Amanda L. Williams
- Department of Surgery, Thomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine
- Rishab Humar
- Department of Surgery, Thomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine
- Rosemary A. Hoffman
- Department of Surgery, Thomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine
- Warren D. Shlomchik
- Department of Surgery, Thomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine
- Martin H. Oberbarnscheidt
- Department of Surgery, Thomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine
- Fadi G. Lakkis
- Department of Surgery, Thomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine
- Adrian E. Morelli
- Department of Surgery, Thomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine
- DOI
- https://doi.org/10.1038/ncomms12623
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 12
Abstract
Blocking T cell activation in organ transplantation is important to prevent rejection. Here the authors show that unconventional monocyte-derived host dendritic cells enter allogeneic grafts to amplify the T cell response outside lymph nodes.
