Nature Communications (Sep 2021)

The leukemic oncogene EVI1 hijacks a MYC super-enhancer by CTCF-facilitated loops

  • Sophie Ottema,
  • Roger Mulet-Lazaro,
  • Claudia Erpelinck-Verschueren,
  • Stanley van Herk,
  • Marije Havermans,
  • Andrea Arricibita Varea,
  • Michael Vermeulen,
  • H. Berna Beverloo,
  • Stefan Gröschel,
  • Torsten Haferlach,
  • Claudia Haferlach,
  • Bas J. Wouters,
  • Eric Bindels,
  • Leonie Smeenk,
  • Ruud Delwel

DOI
https://doi.org/10.1038/s41467-021-25862-3
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 13

Abstract

Read online

Chromosome rearrangements can be a cause of altered oncogene expression in cancer, such as a 3q26 translocation in some acute myeloid leukemias (AML) that leads to overexpression of EVI1. Here the authors engineer this rearrangement in a cell line and show that EVI1 overexpression is a result of ‘enhancer hijacking’ of the MYC superenhancer, which is facilitated by CTCF-mediated loops.