Pediatric Acute Lymphoblastic Leukemia: Efficacy and safety of recombinant E. coli-asparaginase in infants (less than one year of age) with acute lymphoblastic leukemia

Inge van der Sluis; Anja Möricke; Gabriele Escherich; Arend von Stackelberg; Wolfgang Holter; Thomas Klingebiel; Christian Flotho; Sabine Legien; Wim Tissing; Marc Bierings; Cecile Guimbal-Schmolck; Uwe Pichlmeier; Hans-Jürgen Kühnel; Rob Pieters

doi:10.3324/haematol.2013.090563

Haematologica (Nov 2013)

Pediatric Acute Lymphoblastic Leukemia: Efficacy and safety of recombinant E. coli-asparaginase in infants (less than one year of age) with acute lymphoblastic leukemia

Inge van der Sluis,
Anja Möricke,
Gabriele Escherich,
Arend von Stackelberg,
Wolfgang Holter,
Thomas Klingebiel,
Christian Flotho,
Sabine Legien,
Wim Tissing,
Marc Bierings,
Cecile Guimbal-Schmolck,
Uwe Pichlmeier,
Hans-Jürgen Kühnel,
Rob Pieters

Affiliations

Inge van der Sluis: Department of Pediatric Oncology and Hematology, Erasmus MC-Sophia Children’s Hospital, Rotterdam, The Netherlands
Anja Möricke: Department of Pediatrics, University Hospital Schleswig-Holstein, Campus Kiel, Germany
Gabriele Escherich: University Medical Center Eppendorf, Clinic of Pediatric Hematology/Oncology, Hamburg, Germany
Arend von Stackelberg: Department of Pediatric Oncology/Hematology, Charité University Hospital Berlin, Germany
Wolfgang Holter: Pediatric Hematology and Oncology, University Hospital Erlangen, Germany
Thomas Klingebiel: Hospital for Children and Adolescents II/III, University Hospital Frankfurt, Germany
Christian Flotho: Division of Pediatric Hematology/Oncology, Department of Pediatric and Adolescent Medicine, University of Freiburg, Germany
Sabine Legien: Olgahospital, Pediatrics 5 (Oncology, Hematology, Immunology), Klinikum Stuttgart, Germany
Wim Tissing: Department of Pediatric Oncology/Hematology, Beatrix Children’s Hospital, University Medical Center Groningen, The Netherlands
Marc Bierings: Department of Pediatric Oncology/Hematology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, The Netherlands
Cecile Guimbal-Schmolck: medac GmbH, Hamburg, Germany
Uwe Pichlmeier: medac GmbH, Hamburg, Germany
Hans-Jürgen Kühnel: medac GmbH, Hamburg, Germany
Rob Pieters: Department of Pediatric Oncology and Hematology, Erasmus MC-Sophia Children’s Hospital, Rotterdam, The Netherlands

DOI: https://doi.org/10.3324/haematol.2013.090563
Journal volume & issue: Vol. 98, no. 11

Abstract

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The pharmacokinetics, pharmacodynamics, efficacy and safety of a new recombinant E. coli-asparaginase preparation were evaluated in infants (

Published in Haematologica

ISSN: 0390-6078 (Print); 1592-8721 (Online)
Publisher: Ferrata Storti Foundation
Country of publisher: Italy
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the blood and blood-forming organs
Website: http://www.haematologica.org

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