TRPM7 kinase-mediated immunomodulation in macrophage plays a central role in magnesium ion-induced bone regeneration

Wei Qiao; Karen H. M. Wong; Jie Shen; Wenhao Wang; Jun Wu; Jinhua Li; Zhengjie Lin; Zetao Chen; Jukka P. Matinlinna; Yufeng Zheng; Shuilin Wu; Xuanyong Liu; Keng Po Lai; Zhuofan Chen; Yun Wah Lam; Kenneth M. C. Cheung; Kelvin W. K. Yeung

doi:10.1038/s41467-021-23005-2

Nature Communications (May 2021)

TRPM7 kinase-mediated immunomodulation in macrophage plays a central role in magnesium ion-induced bone regeneration

Wei Qiao,
Karen H. M. Wong,
Jie Shen,
Wenhao Wang,
Jun Wu,
Jinhua Li,
Zhengjie Lin,
Zetao Chen,
Jukka P. Matinlinna,
Yufeng Zheng,
Shuilin Wu,
Xuanyong Liu,
Keng Po Lai,
Zhuofan Chen,
Yun Wah Lam,
Kenneth M. C. Cheung,
Kelvin W. K. Yeung

Affiliations

Wei Qiao: Department of Orthopaedics and Traumatology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
Karen H. M. Wong: Department of Orthopaedics and Traumatology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
Jie Shen: Department of Orthopaedics and Traumatology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
Wenhao Wang: Department of Orthopaedics and Traumatology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
Jun Wu: Department of Orthopaedics and Traumatology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
Jinhua Li: Department of Orthopaedics and Traumatology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
Zhengjie Lin: Department of Orthopaedics and Traumatology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
Zetao Chen: Department of Oral Implantology, Hospital of Stomatology, Guanghua School of Stomatology, Institute of Stomatological Research, Sun Yat-sen University
Jukka P. Matinlinna: Dental Materials Science, Applied Oral Sciences, Faculty of Dentistry, The University of Hong Kong
Yufeng Zheng: State Key Laboratory for Turbulence and Complex System and Department of Materials Science and Engineering, College of Engineering, Peking University
Shuilin Wu: School of Materials Science and Engineering, Tianjin University
Xuanyong Liu: State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences
Keng Po Lai: Guangxi Key Laboratory of Tumor Immunology and Microenvironmental Regulation, Guilin Medical University
Zhuofan Chen: Zhujiang New Town Clinic, Hospital of Stomatology, Sun Yat-sen University
Yun Wah Lam: Department of Chemistry, City University of Hong Kong, Kowloon Tong
Kenneth M. C. Cheung: Department of Orthopaedics and Traumatology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
Kelvin W. K. Yeung: Department of Orthopaedics and Traumatology, Li Ka Shing Faculty of Medicine, The University of Hong Kong

DOI: https://doi.org/10.1038/s41467-021-23005-2
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 15

Abstract

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Supplementation of magnesium (Mg2+) or its inclusion in biomaterials has beneficial effects for bone formation, but it has also been reported that it can have detrimental effects. Here, the authors analyse dose- and time-dependent effects of Mg2+ on bone regeneration and show that it can stimulate monocyte-macrophage lineage cells to support bone formation in the early phases of repair, but inhibit bone repair and mineralization in later stages by promoting a pro-inflammatory environment.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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