Nature Communications (Oct 2021)
Bone marrow derived stromal cells from myelodysplastic syndromes are altered but not clonally mutated in vivo
- Johann-Christoph Jann,
- Maximilian Mossner,
- Vladimir Riabov,
- Eva Altrock,
- Nanni Schmitt,
- Johanna Flach,
- Qingyu Xu,
- Verena Nowak,
- Julia Obländer,
- Iris Palme,
- Nadine Weimer,
- Alexander Streuer,
- Ahmed Jawhar,
- Ali Darwich,
- Mohammad Jawhar,
- Georgia Metzgeroth,
- Florian Nolte,
- Wolf-Karsten Hofmann,
- Daniel Nowak
Affiliations
- Johann-Christoph Jann
- Department of Hematology and Oncology, Medical Faculty Mannheim of the Heidelberg University
- Maximilian Mossner
- Department of Hematology and Oncology, Medical Faculty Mannheim of the Heidelberg University
- Vladimir Riabov
- Department of Hematology and Oncology, Medical Faculty Mannheim of the Heidelberg University
- Eva Altrock
- Department of Hematology and Oncology, Medical Faculty Mannheim of the Heidelberg University
- Nanni Schmitt
- Department of Hematology and Oncology, Medical Faculty Mannheim of the Heidelberg University
- Johanna Flach
- Department of Hematology and Oncology, Medical Faculty Mannheim of the Heidelberg University
- Qingyu Xu
- Department of Hematology and Oncology, Medical Faculty Mannheim of the Heidelberg University
- Verena Nowak
- Department of Hematology and Oncology, Medical Faculty Mannheim of the Heidelberg University
- Julia Obländer
- Department of Hematology and Oncology, Medical Faculty Mannheim of the Heidelberg University
- Iris Palme
- Department of Hematology and Oncology, Medical Faculty Mannheim of the Heidelberg University
- Nadine Weimer
- Department of Hematology and Oncology, Medical Faculty Mannheim of the Heidelberg University
- Alexander Streuer
- Department of Hematology and Oncology, Medical Faculty Mannheim of the Heidelberg University
- Ahmed Jawhar
- Department of Orthopedic Surgery, Medical Faculty Mannheim of the Heidelberg University
- Ali Darwich
- Department of Orthopedic Surgery, Medical Faculty Mannheim of the Heidelberg University
- Mohammad Jawhar
- Department of Hematology and Oncology, Medical Faculty Mannheim of the Heidelberg University
- Georgia Metzgeroth
- Department of Hematology and Oncology, Medical Faculty Mannheim of the Heidelberg University
- Florian Nolte
- Department of Hematology and Oncology, Medical Faculty Mannheim of the Heidelberg University
- Wolf-Karsten Hofmann
- Department of Hematology and Oncology, Medical Faculty Mannheim of the Heidelberg University
- Daniel Nowak
- Department of Hematology and Oncology, Medical Faculty Mannheim of the Heidelberg University
- DOI
- https://doi.org/10.1038/s41467-021-26424-3
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 11
Abstract
Bone marrow-derived mesenchymal stroma cells (MSCs) in myeloid neoplasia have been hypothesized to carry somatic mutations and contribute to pathogenesis. Here the authors analyse ex-vivo cultures and primary MSCs derived from patients with myelodysplastic syndromes, finding functional alterations but no evidence of clonal mutations.
