Nature Communications (Aug 2021)
The pathogenesis of mesothelioma is driven by a dysregulated translatome
- Stefano Grosso,
- Alberto Marini,
- Katarina Gyuraszova,
- Johan Vande Voorde,
- Aristeidis Sfakianos,
- Gavin D. Garland,
- Angela Rubio Tenor,
- Ryan Mordue,
- Tanya Chernova,
- Nobu Morone,
- Marco Sereno,
- Claire P. Smith,
- Leah Officer,
- Pooyeh Farahmand,
- Claire Rooney,
- David Sumpton,
- Madhumita Das,
- Ana Teodósio,
- Catherine Ficken,
- Maria Guerra Martin,
- Ruth V. Spriggs,
- Xiao-Ming Sun,
- Martin Bushell,
- Owen J. Sansom,
- Daniel Murphy,
- Marion MacFarlane,
- John P. C. Le Quesne,
- Anne E. Willis
Affiliations
- Stefano Grosso
- MRC Toxicology Unit, Gleeson Building, University of Cambridge
- Alberto Marini
- MRC Toxicology Unit, Gleeson Building, University of Cambridge
- Katarina Gyuraszova
- Institute of Cancer Sciences, University of Glasgow
- Johan Vande Voorde
- Cancer Research UK Beatson Institute, Garscube Estate
- Aristeidis Sfakianos
- MRC Toxicology Unit, Gleeson Building, University of Cambridge
- Gavin D. Garland
- MRC Toxicology Unit, Gleeson Building, University of Cambridge
- Angela Rubio Tenor
- MRC Toxicology Unit, Gleeson Building, University of Cambridge
- Ryan Mordue
- MRC Toxicology Unit, Gleeson Building, University of Cambridge
- Tanya Chernova
- MRC Toxicology Unit, Gleeson Building, University of Cambridge
- Nobu Morone
- MRC Toxicology Unit, Gleeson Building, University of Cambridge
- Marco Sereno
- MRC Toxicology Unit, Gleeson Building, University of Cambridge
- Claire P. Smith
- MRC Toxicology Unit, Gleeson Building, University of Cambridge
- Leah Officer
- MRC Toxicology Unit, Gleeson Building, University of Cambridge
- Pooyeh Farahmand
- Institute of Cancer Sciences, University of Glasgow
- Claire Rooney
- Institute of Cancer Sciences, University of Glasgow
- David Sumpton
- Cancer Research UK Beatson Institute, Garscube Estate
- Madhumita Das
- MRC Toxicology Unit, Gleeson Building, University of Cambridge
- Ana Teodósio
- MRC Toxicology Unit, Gleeson Building, University of Cambridge
- Catherine Ficken
- MRC Toxicology Unit, Gleeson Building, University of Cambridge
- Maria Guerra Martin
- MRC Toxicology Unit, Gleeson Building, University of Cambridge
- Ruth V. Spriggs
- MRC Toxicology Unit, Gleeson Building, University of Cambridge
- Xiao-Ming Sun
- MRC Toxicology Unit, Gleeson Building, University of Cambridge
- Martin Bushell
- Institute of Cancer Sciences, University of Glasgow
- Owen J. Sansom
- Institute of Cancer Sciences, University of Glasgow
- Daniel Murphy
- Institute of Cancer Sciences, University of Glasgow
- Marion MacFarlane
- MRC Toxicology Unit, Gleeson Building, University of Cambridge
- John P. C. Le Quesne
- MRC Toxicology Unit, Gleeson Building, University of Cambridge
- Anne E. Willis
- MRC Toxicology Unit, Gleeson Building, University of Cambridge
- DOI
- https://doi.org/10.1038/s41467-021-25173-7
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 17
Abstract
Treating malignant pleural mesothelioma (MpM) is challenging due to a lack of druggable genes, but other molecular features could be clinically useful. Here the authors profile mRNA translation dysregulation in MpM cell lines using polysome profiling, and identify mTORC1 and 2 as potential pharmacological targets.
