Evaluation of titanium-prepared platelet-rich fibrin and leucocyteplatelet-rich fibrin in the treatment of intra-bony defects: Arandomized clinical trial

Abstract

Background. Various treatment modalities, such as leucocyte platelet-rich fibrin (L-PRF), bone grafts,and membranes, have been used for the restoration of lost periodontal tissues. Titanium-preparedplatelet-rich fibrin (T-PRF) has attracted attention for its proper haemocompatibility, thick fibrinmeshwork, and long resorption time. The present study aimed to evaluate the effectiveness of T-PRFand L-PRF in the management of intra-bony defects based on clinical and radiographic criteria. Methods. Twenty-six subjects with 34 intra-bony 3- walled defects were divided into two groups (n=17)and treated with T-PRF or L-PRF. Clinical and radiographic measurements were recorded at baselineand 6- , 3- and 9- month intervals and tabulated on Microsoft Excel spreadsheets. For intra- and intergroupcomparisons, paired and unpaired t-tests were performed. P<0.05 was set as statistically significant Results. Intra-group comparisons revealed statistically significant differences (P<0.05) from baseline inboth groups regarding clinical measurements. On intergroup comparison, the T-PRF group exhibited asignificantly higher defect fill compared to the L-PRF group (P<0.05). Conclusion. Within the limits of the present study, T-PRF seems to be a better alternative to L-PRF inthe treatment of intra-bony defects.

Keywords

• bone regeneration
• chronic periodontitis
• periodontal pocket
• debridement
• platelet-rich fibrin