Gut immunity in a protochordate involves a secreted immunoglobulin-type mediator binding host chitin and bacteria

Abstract

Protochordates, including Ciona intestinalis, lack an adaptive immune system but possess innate immune receptors, including the secreted immunoglobulin V-region-containing VCBPs. Here the authors show that VCBP-C of Cionabinds gut bacteria and chitin-rich gut mucosa, influences biofilm formation and likely plays a role in gut homeostasis.