Molecules (Mar 2020)

Comprehensive Effects of Near-Infrared Multifunctional Liposomes on Cancer Cells

  • Yiqing Deng,
  • Huaying Huang,
  • Mengxiao Chen,
  • Gang Chen,
  • Wangcai Zou,
  • Yanqing Zhao,
  • Qiang Zhao

DOI
https://doi.org/10.3390/molecules25051098
Journal volume & issue
Vol. 25, no. 5
p. 1098

Abstract

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Multifunctional theranostic systems are a recent important development of medical research. We combined the characteristics of near-infrared luminescent quantum dots and thermosensitive magnetoliposomes to develop a multifunctional nano-diagnostic material. This system is based on near-infrared magnetic thermosensitive liposomes, which encapsulate drugs and can control drug localization and release. After incubating cancer cells with the liposomes, the state of the cells was analyzed in real time by near-infrared imaging. Cell viability was significantly inhibited by heat treatment or alternating magnetic field treatment, which thus improved the anti-cancer properties of the liposomes. In the future, by combining near-infrared imaging technology and an external high-frequency alternating magnetic field, we could not only detect cancer cells noninvasively but also conduct image-guided treatments for cancer.

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