Treatment strategies for psoriasis using flavonoids from traditional Chinese medicine

Abstract

Introduction: : The persistent inflammatory skin condition psoriasis disorder poses a significant health burden globally. This review explores recent advancements in treating psoriasis by harnessing the therapeutic potential of flavonoids, naturally occurring substances having anti-inflammatory and antioxidant. Methods: The following keywords were used to search the online databases: Flavonoid, psoriasis, traditional applications, Chinese herb; Scopus, web of science, and PubMed. Consequently, this review set out to compile a synopsis of the documented phytochemistry and recent advancement of the selected plant species. Results: : Specifically, flavonoids like quercetin and kaempferol have demonstrated promising results in mitigating psoriatic symptoms by targeting key molecular pathways. In conjunction with these advancements, a novel drug delivery system has been introduced to optimize flavonoid efficacy. This innovative approach employs nanocarrier systems, such as solid lipid nanoparticles (SLnp) and liposomes, to enhance the bioavailability and stability of flavonoids. By ensuring controlled release and targeted delivery, these systems address the challenges of poor solubility and maximize the therapeutic impact on psoriatic lesions. This dual strategy, integrating flavonoid-based treatment advancements with an innovative drug delivery system, presents a comprehensive and promising avenue for improving psoriasis management. Discussion: : Future research and clinical validation are crucial to establishing the safety and efficacy of this integrated approach, potentially reshaping the landscape of psoriasis therapeutics.

Keywords

• Psoriasis
• Liposome
• Nanocarrier
• Flavonoids
• Bioactive compound
• Inflammation