Clinical outcomes of sildenafil application in patients of poor endometrial development

Meiling Guo; Yuchen Yan; Jianan Lv; Hua Xin; Wei Zhou; Na Yu; Mingdi Xia; Jing Li; Qian Zhang; Junhao Yan

Gynecology and Obstetrics Clinical Medicine (Mar 2022)

Clinical outcomes of sildenafil application in patients of poor endometrial development

Meiling Guo,
Yuchen Yan,
Jianan Lv,
Hua Xin,
Wei Zhou,
Na Yu,
Mingdi Xia,
Jing Li,
Qian Zhang,
Junhao Yan

Affiliations

Meiling Guo: Qingdao Women and Children's Hospital, Qingdao, Shandong, 266021, China
Yuchen Yan: Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China; Key laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan, Shandong, 250012, China; Shandong Key Laboratory of Reproductive Medicine, Jinan, Shandong, 250012, China; Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong, 250012, China; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, 250012, China
Jianan Lv: Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China; Key laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan, Shandong, 250012, China; Shandong Key Laboratory of Reproductive Medicine, Jinan, Shandong, 250012, China; Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong, 250012, China; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, 250012, China
Hua Xin: Department of Ultrasonography, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, China
Wei Zhou: Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China; Key laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan, Shandong, 250012, China; Shandong Key Laboratory of Reproductive Medicine, Jinan, Shandong, 250012, China; Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong, 250012, China; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, 250012, China
Na Yu: Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China; Key laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan, Shandong, 250012, China; Shandong Key Laboratory of Reproductive Medicine, Jinan, Shandong, 250012, China; Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong, 250012, China; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, 250012, China
Mingdi Xia: Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China; Key laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan, Shandong, 250012, China; Shandong Key Laboratory of Reproductive Medicine, Jinan, Shandong, 250012, China; Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong, 250012, China; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, 250012, China
Jing Li: Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China; Key laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan, Shandong, 250012, China; Shandong Key Laboratory of Reproductive Medicine, Jinan, Shandong, 250012, China; Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong, 250012, China; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, 250012, China
Qian Zhang: Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China; Key laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan, Shandong, 250012, China; Shandong Key Laboratory of Reproductive Medicine, Jinan, Shandong, 250012, China; Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong, 250012, China; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, 250012, China
Junhao Yan: Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China; Key laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan, Shandong, 250012, China; Shandong Key Laboratory of Reproductive Medicine, Jinan, Shandong, 250012, China; Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong, 250012, China; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, 250012, China; Corresponding author. Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China.

Journal volume & issue: Vol. 2, no. 1
pp. 14 – 19

Abstract

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Objective: To determine whether sildenafil has an effect on pregnancy outcomes in patients with poor endometrial development. Methods: This study included 472 infertility patients who underwent in vitro fertilization/intracytoplasmatic sperm injection and frozen-thawed embryo transfer (IVF/ICSI-FET) and subsequently suffered from poor endometrial development during hormone replacement cycle (HRC) from April 2017 to July 2019. The patients were divided into two groups: the sildenafil group (n = 88) and the control group (n = 384). We analyzed endometrial thicknesses and types on endometrial transformation day, as well as pregnancy outcomes after FET (biochemical pregnancy, clinical pregnancy, early abortion, late abortion, and live birth rates) between the two groups. Results: After adjusting for confounding factors, we found no significant differences in endometrial thicknesses and types on endometrial transformation day between the sildenafil group and the control group (0.79 ± 0.08 vs 0.81 ± 0.09, P = 0.144; 79.76% vs83.87%, P = 0.402). There were also no statistically significant differences in biochemical pregnancy rate (75.0% vs 76.8%, P = 0.892), clinical pregnancy rate (59.09% vs 69.53%, P = 0.087), early abortion rate (17.31% vs 14.61%, P = 0.557), late abortion rate (3.85% vs 4.49%, P = 0.859), or live birth rate (45.45% vs 55.47%, P = 0.101) between the two groups. In subgroup analysis, the application of sildenafil was unable to improve endometrial thickness (group one: 0.80 ± 0.08 cm vs 0.82 ± 0.08 cm; group two:0.78 ± 0.08 cm vs 0.80 ± 0.10 cm; group three:0.75 ± 0.11 cm vs 0.77 ± 0.08 cm, p > 0.05) and type endometrium on transformation day (group one: 78.57% vs 86.78%; group two: 80.65% vs 77.78%; group three: 81.82% vs 83.78%, p > 0.05). Moreover, sildenafil use was not closely associated with clinical pregnancy outcomes, clinical pregnancy rate, early abortion rate, late abortion rate, and live birth rate (p > 0.05). Conclusions: Sildenafil did not benefit endometrial development and pregnancy outcomes in patients with poor endometrial development during the hormone replacement cycle.

Published in Gynecology and Obstetrics Clinical Medicine

ISSN: 2097-0587 (Print); 2667-1646 (Online)
Publisher: BMJ Publishing Group
Country of publisher: United Kingdom
LCC subjects: Medicine: Gynecology and obstetrics
Website: https://gocm.bmj.com

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