Nature Communications (Jun 2018)
TLR9 activation via microglial glucocorticoid receptors contributes to degeneration of midbrain dopamine neurons
- Layal Maatouk,
- Anne-Claire Compagnion,
- Maria-Angeles Carrillo-de Sauvage,
- Alexis-Pierre Bemelmans,
- Sabrina Leclere-Turbant,
- Vincent Cirotteau,
- Mira Tohme,
- Allen Beke,
- Michaël Trichet,
- Virginie Bazin,
- Bobby N. Trawick,
- Richard M. Ransohoff,
- François Tronche,
- Bénédicte Manoury,
- Sheela Vyas
Affiliations
- Layal Maatouk
- Institute of Biology Paris Seine, Gene Regulation and Adaptive Behaviors Team, Department of Neuroscience Paris Seine, Sorbonne Université, CNRS UMR 8246 & INSERM U1130
- Anne-Claire Compagnion
- Institute of Biology Paris Seine, Gene Regulation and Adaptive Behaviors Team, Department of Neuroscience Paris Seine, Sorbonne Université, CNRS UMR 8246 & INSERM U1130
- Maria-Angeles Carrillo-de Sauvage
- CEA, DRF, Institut François Jacob, Neurodegenerative Diseases Laboratory, Molecular Imaging Research Center (MIRCen), CNRS, CEA, Université Paris-Sud, Université Paris-Saclay (UMR9199)
- Alexis-Pierre Bemelmans
- CEA, DRF, Institut François Jacob, Neurodegenerative Diseases Laboratory, Molecular Imaging Research Center (MIRCen), CNRS, CEA, Université Paris-Sud, Université Paris-Saclay (UMR9199)
- Sabrina Leclere-Turbant
- IHU-A-ICM–Neuro-CEB, Plateforme de Ressources Biologiques (PRB), Hôpital de la Pitié-Salpétrière
- Vincent Cirotteau
- Institute of Biology Paris Seine, Gene Regulation and Adaptive Behaviors Team, Department of Neuroscience Paris Seine, Sorbonne Université, CNRS UMR 8246 & INSERM U1130
- Mira Tohme
- INEM, INSERM U1151-CNRS UMR 8253, Hôpital Necker, Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine
- Allen Beke
- Institute of Biology Paris Seine, Gene Regulation and Adaptive Behaviors Team, Department of Neuroscience Paris Seine, Sorbonne Université, CNRS UMR 8246 & INSERM U1130
- Michaël Trichet
- Institute of Biology Paris Seine, Electron Microscopy Facility, Sorbonne Université FR3631
- Virginie Bazin
- Institute of Biology Paris Seine, Electron Microscopy Facility, Sorbonne Université FR3631
- Bobby N. Trawick
- Center for Organic Chemistry, Mallinckrodt Pharmaceuticals
- Richard M. Ransohoff
- Third Rock Ventures
- François Tronche
- Institute of Biology Paris Seine, Gene Regulation and Adaptive Behaviors Team, Department of Neuroscience Paris Seine, Sorbonne Université, CNRS UMR 8246 & INSERM U1130
- Bénédicte Manoury
- INEM, INSERM U1151-CNRS UMR 8253, Hôpital Necker, Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine
- Sheela Vyas
- Institute of Biology Paris Seine, Gene Regulation and Adaptive Behaviors Team, Department of Neuroscience Paris Seine, Sorbonne Université, CNRS UMR 8246 & INSERM U1130
- DOI
- https://doi.org/10.1038/s41467-018-04569-y
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 15
Abstract
Inflammation is a component of Parkinson’s disease. Here the authors show that activation of Toll-like receptor 9 controlled by microglial glucocorticoid receptor signaling, contributes to dopamine neuron loss in a model of Parkinson’s disease.
