Сибирский онкологический журнал (Sep 2017)
RADIOTHERAPY IN MANAGEMENT OF BRCA-POSITIVE OVARIAN CANCER
Abstract
Cancer cells with the loss of BRCA 1 or BRCA 2 function are unable to repair DNA double-strand breaks and demonstrate the increased sensitivity to various DNA-damaging agents. We aimed to describe successful treatment outcomes in two patients with BRCA1-associated ovarian cancer, who showed a complete clinical response to radiotherapy in combination with platinum-based chemotherapy. The progression-free survival was 11 months in one case and 8 months in another case.
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