Anti-tumor activity of sulfated polysaccharides from Sargassum fusiforme

Miao Yu; Yubin Ji; Zheng Qi; Di Cui; Guosong Xin; Bing Wang; Yue Cao; Dandan Wang

Saudi Pharmaceutical Journal (May 2017)

Anti-tumor activity of sulfated polysaccharides from Sargassum fusiforme

Miao Yu,
Yubin Ji,
Zheng Qi,
Di Cui,
Guosong Xin,
Bing Wang,
Yue Cao,
Dandan Wang

Affiliations

Miao Yu: Research Center on Life Sciences and Environmental Sciences, Harbin University of Commerce, Harbin 150076, China; Engineering Research Center of Natural Anticancer Drugs, Ministry of Education, Harbin 150076, China
Yubin Ji: Research Center on Life Sciences and Environmental Sciences, Harbin University of Commerce, Harbin 150076, China; Engineering Research Center of Natural Anticancer Drugs, Ministry of Education, Harbin 150076, China; Corresponding author at: Research Center on Life Sciences and Environmental Sciences, Harbin University of Commerce, Harbin 150076, China.
Zheng Qi: Research Center on Life Sciences and Environmental Sciences, Harbin University of Commerce, Harbin 150076, China; Engineering Research Center of Natural Anticancer Drugs, Ministry of Education, Harbin 150076, China
Di Cui: Research Center on Life Sciences and Environmental Sciences, Harbin University of Commerce, Harbin 150076, China; Engineering Research Center of Natural Anticancer Drugs, Ministry of Education, Harbin 150076, China
Guosong Xin: Research Center on Life Sciences and Environmental Sciences, Harbin University of Commerce, Harbin 150076, China; Engineering Research Center of Natural Anticancer Drugs, Ministry of Education, Harbin 150076, China
Bing Wang: Research Center on Life Sciences and Environmental Sciences, Harbin University of Commerce, Harbin 150076, China; Engineering Research Center of Natural Anticancer Drugs, Ministry of Education, Harbin 150076, China
Yue Cao: Research Center on Life Sciences and Environmental Sciences, Harbin University of Commerce, Harbin 150076, China
Dandan Wang: Research Center on Life Sciences and Environmental Sciences, Harbin University of Commerce, Harbin 150076, China

Journal volume & issue: Vol. 25, no. 4
pp. 464 – 468

Abstract

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In this study, our purpose is to discover the correlation between polysaccharides sulfated structure and anti-tumor activity. Sulfated polysaccharide from Sargassum fusiforme were synthesized with the chlorosulfonic acid pyridine method. The inhibitory effect of Sargassum fusiforme polysaccharides and the application of MTT assay before and after chemical modification on the proliferation of hepatocellular carcinoma HepG-2 cells in vitro were studied. Sulfated polysaccharide from sargassum fusiforme DS is 0.803. The modified polysaccharide has certain inhibitory effect on HepG-2 cells, and its inhibition on the cells growth has improved compared with the original SFPs. The sulfated polysaccharide from Sargassum fusiforme has the ability to enhance anti-tumor activities. Keywords: Sargassum fusiforme polysaccharide, Sulfation, MTT method, Anti-tumor

Published in Saudi Pharmaceutical Journal

ISSN: 1319-0164 (Print)
Publisher: Elsevier
Country of publisher: Saudi Arabia
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: http://www.journals.elsevier.com/saudi-pharmaceutical-journal/

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