Drugs in R&D (Mar 2023)

Case Report: Simultaneously Induced Neutropenia and Hemolysis After a Single Metamizole Dose

  • Raphael Allgaier,
  • Arne Kandulski,
  • Karsten Gülow,
  • Lars Maier,
  • Martina Müller,
  • Hauke Christian Tews

DOI
https://doi.org/10.1007/s40268-023-00415-9
Journal volume & issue
Vol. 23, no. 2
pp. 93 – 98

Abstract

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Abstract Background and objective Metamizole is a non-opioid ampyrone sulfonate compound with potent analgesic, antipyretic, and spasmolytic effects. Agranulocytosis is a rare life-threatening complication of metamizole. Case Here, we present the case of a 62-year-old patient who developed agranulocytosis as well as hemolysis after a single administration of metamizole. Conclusion This case illustrates the inherent allergic potential of metamizole and its effects on different hematopoietic cell types.