Application of mesenchymal stem/stromal cells in periodontal regeneration: Opportunities and challenges

Pan Gao; Mikihito Kajiya; Souta Motoike; Makoto Ikeya; Jingmei Yang

Japanese Dental Science Review (Dec 2024)

Application of mesenchymal stem/stromal cells in periodontal regeneration: Opportunities and challenges

Pan Gao,
Mikihito Kajiya,
Souta Motoike,
Makoto Ikeya,
Jingmei Yang

Affiliations

Pan Gao: State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Department of General Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, Sichuan, China
Mikihito Kajiya: Department of Periodontal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan
Souta Motoike: Department of Periodontal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan
Makoto Ikeya: Department of Clinical Application, Center for iPS Cell Research and Application, Kyoto University, Kyoto 606-8507, Japan; Correspondence to: Department of Clinical Application, Center for iPS Cell Research and Application, Kyoto University, 53, Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan.
Jingmei Yang: State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Department of Periodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, Sichuan, China; Correspondence to: Department of Periodontics, West China Hospital of Stomatology, Sichuan University, No.14, 3Rd Section of Ren Min Nan Rd., Chengdu, Sichuan 610041, China.

Journal volume & issue: Vol. 60
pp. 95 – 108

Abstract

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Guided tissue regeneration (GTR) has been widely used in the periodontal treatment of intrabony and furcation defects for nearly four decades. The treatment outcomes have shown effectiveness in reducing pocket depth, improving attachment gain and bone filling in periodontal tissue. Although applying GTR could reconstruct the periodontal tissue, the surgical indications are relatively narrow, and some complications and race ethic problems bring new challenges. Therefore, it is challenging to achieve a consensus concerning the clinical benefits of GTR. With the appearance of stem cell-based regenerative medicine, mesenchymal stem/stromal cells (MSCs) have been considered a promising cell resource for periodontal regeneration. In this review, we highlight preclinical and clinical periodontal regeneration using MSCs derived from distinct origins, including non-odontogenic and odontogenic tissues and induced pluripotent stem cells, and discuss the transplantation procedures, therapeutic mechanisms, and concerns to evaluate the effectiveness of MSCs.

Published in Japanese Dental Science Review

ISSN: 1882-7616 (Print); 2213-6851 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Dentistry
Website: https://www.journals.elsevier.com/japanese-dental-science-review

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