Influence of pharmacogenetics on the diversity of response to statins associated with adverse drug reactions

Abstract

Statins are one of the most prescribed medications in developed countries as the treatment of choice for reducing cholesterol and preventing cardiovascular diseases. However, a large proportion of patients experience adverse drug reactions, especially myotoxicity. Among the factors that influence the diversity of response, pharmacogenetics emerges as a relevant factor of influence in inter-individual differences in response to statins and can be useful in the prevention of adverse drug effects.

Keywords

• statins
• pharmacogenetics
• adverse reactions
• slco1b1
• precision medicine