Item-level analyses reveal genetic heterogeneity in neuroticism

Mats Nagel; Kyoko Watanabe; Sven Stringer; Danielle Posthuma; Sophie van der Sluis

doi:10.1038/s41467-018-03242-8

Nature Communications (Mar 2018)

Item-level analyses reveal genetic heterogeneity in neuroticism

Mats Nagel,
Kyoko Watanabe,
Sven Stringer,
Danielle Posthuma,
Sophie van der Sluis

Affiliations

Mats Nagel: Department of Clinical Genetics, Section Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU Medical Centre
Kyoko Watanabe: Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam
Sven Stringer: Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam
Danielle Posthuma: Department of Clinical Genetics, Section Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU Medical Centre
Sophie van der Sluis: Department of Clinical Genetics, Section Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU Medical Centre

DOI: https://doi.org/10.1038/s41467-018-03242-8
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 10

Abstract

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Neuroticism can be assessed as a composite score of individual items. Here, Nagel et al. perform genetic association studies for 12 neuroticism items and the sum-score and demonstrate genetic heterogeneity at the item-level.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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