Nature Communications (Sep 2022)
Fatty acids homeostasis during fasting predicts protection from chemotherapy toxicity
- Marta Barradas,
- Adrián Plaza,
- Gonzalo Colmenarejo,
- Iolanda Lázaro,
- Luis Filipe Costa-Machado,
- Roberto Martín-Hernández,
- Victor Micó,
- José Luis López-Aceituno,
- Jesús Herranz,
- Cristina Pantoja,
- Hector Tejero,
- Alberto Diaz-Ruiz,
- Fatima Al-Shahrour,
- Lidia Daimiel,
- Viviana Loria-Kohen,
- Ana Ramirez de Molina,
- Alejo Efeyan,
- Manuel Serrano,
- Oscar J. Pozo,
- Aleix Sala-Vila,
- Pablo J. Fernandez-Marcos
Affiliations
- Marta Barradas
- Metabolic Syndrome Group—BIOPROMET, CEI UAM+CSIC, Madrid Institute for Advanced Studies—IMDEA Food
- Adrián Plaza
- Metabolic Syndrome Group—BIOPROMET, CEI UAM+CSIC, Madrid Institute for Advanced Studies—IMDEA Food
- Gonzalo Colmenarejo
- Biostatistics and Bioinformatics Unit, CEI UAM+CSIC, Madrid Institute for Advanced Studies—IMDEA Food
- Iolanda Lázaro
- Cardiovascular risk and nutrition, Hospital del Mar Medical Research Institute—IMIM
- Luis Filipe Costa-Machado
- Metabolic Syndrome Group—BIOPROMET, CEI UAM+CSIC, Madrid Institute for Advanced Studies—IMDEA Food
- Roberto Martín-Hernández
- Biostatistics and Bioinformatics Unit, CEI UAM+CSIC, Madrid Institute for Advanced Studies—IMDEA Food
- Victor Micó
- Nutritional Genomics of Cardiovascular Disease and Obesity, Madrid Institute for Advanced Studies—IMDEA Food
- José Luis López-Aceituno
- Metabolic Syndrome Group—BIOPROMET, CEI UAM+CSIC, Madrid Institute for Advanced Studies—IMDEA Food
- Jesús Herranz
- Biostatistics and Bioinformatics Unit, CEI UAM+CSIC, Madrid Institute for Advanced Studies—IMDEA Food
- Cristina Pantoja
- Metabolic Syndrome Group—BIOPROMET, CEI UAM+CSIC, Madrid Institute for Advanced Studies—IMDEA Food
- Hector Tejero
- Bioinformatics Unit, Spanish National Cancer Research Centre—CNIO
- Alberto Diaz-Ruiz
- Nutritional Interventions Group, Precision Nutrition and Aging, CEI UAM+CSIC, Madrid Institute for Advanced Studies—IMDEA Food
- Fatima Al-Shahrour
- Bioinformatics Unit, Spanish National Cancer Research Centre—CNIO
- Lidia Daimiel
- Nutritional Genomics of Cardiovascular Disease and Obesity, Madrid Institute for Advanced Studies—IMDEA Food
- Viviana Loria-Kohen
- Nutrition and Clinical Trials Unit, Platform GENYAL, CEI UAM+CSIC, Madrid Institute for Advanced Studies—IMDEA Food
- Ana Ramirez de Molina
- Nutrition and Clinical Trials Unit, Platform GENYAL, CEI UAM+CSIC, Madrid Institute for Advanced Studies—IMDEA Food
- Alejo Efeyan
- Metabolism and Cell Signaling Group, Spanish National Cancer Research Centre—CNIO
- Manuel Serrano
- Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology (BIST), Catalan Institution for Research and Advanced Studies (ICREA)
- Oscar J. Pozo
- Applied Metabolomics Research Group, Hospital del Mar Medical Research Institute—(IMIM)
- Aleix Sala-Vila
- Cardiovascular risk and nutrition, Hospital del Mar Medical Research Institute—IMIM
- Pablo J. Fernandez-Marcos
- Metabolic Syndrome Group—BIOPROMET, CEI UAM+CSIC, Madrid Institute for Advanced Studies—IMDEA Food
- DOI
- https://doi.org/10.1038/s41467-022-33352-3
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 22
Abstract
Fasting has been reported to protect from chemotherapy-associated toxicity. Here, the authors show that fatty acid profiles in erythrocyte membranes and gene expression from peripheral blood mononuclear cells are associated to the fasting-mediated benefits during cancer treatment in mice and patients.
