Vìsnik: Kiïvsʹkij Nacìonalʹnij Unìversitet Imenì Tarasa Ševčenka. Bìologìâ (Aug 2016)

Interaction of antitumor cytokine EMAP II with hydroxypropyl-beta-cyclodextrin

  • A. Malyna,
  • O. Kornelyuk

Journal volume & issue
Vol. 69, no. 1
pp. 25 – 28

Abstract

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The interaction of the antitumor cytokine EMAP II with hydroxypropyl-beta-cyclodextrin was investigated by methods of optical spectroscopy. Established that HP-beta-CD binds specifically to EMAP II. The most likely binding site is partially exposed residue Trp126, localized in depressions on the surface of EMAP II along with functionally important lysine-rich cluster.

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