ImmGen report: sexual dimorphism in the immune system transcriptome

Shani Talia Gal-Oz; Barbara Maier; Hideyuki Yoshida; Kumba Seddu; Nitzan Elbaz; Charles Czysz; Or Zuk; Barbara E. Stranger; Hadas Ner-Gaon; Tal Shay

doi:10.1038/s41467-019-12348-6

Nature Communications (Sep 2019)

ImmGen report: sexual dimorphism in the immune system transcriptome

Shani Talia Gal-Oz,
Barbara Maier,
Hideyuki Yoshida,
Kumba Seddu,
Nitzan Elbaz,
Charles Czysz,
Or Zuk,
Barbara E. Stranger,
Hadas Ner-Gaon,
Tal Shay

Affiliations

Shani Talia Gal-Oz: Department of Life Sciences, Ben-Gurion University of the Negev
Barbara Maier: The Precision Immunology Institute & Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai
Hideyuki Yoshida: Department of Immunology, Harvard Medical School
Kumba Seddu: Department of Immunology, Harvard Medical School
Nitzan Elbaz: Department of Life Sciences, Ben-Gurion University of the Negev
Charles Czysz: Section of Genetic Medicine, Institute for Genomics and Systems Biology, University of Chicago
Or Zuk: Department of Statistics, The Hebrew University of Jerusalem
Barbara E. Stranger: Section of Genetic Medicine, Institute for Genomics and Systems Biology, University of Chicago
Hadas Ner-Gaon: Department of Life Sciences, Ben-Gurion University of the Negev
Tal Shay: Department of Life Sciences, Ben-Gurion University of the Negev

DOI: https://doi.org/10.1038/s41467-019-12348-6
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 14

Abstract

Read online

Sexual dimorphism is observed frequently in immune disorders, but the underlying insights are still unclear. Here the authors analyze transcriptome and epigenome changes induced by interferon in various mouse immune cell types, and find only a restricted set of sexual dimorphism genes in innate immunity and macrophages.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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