Nature Communications (Aug 2018)
Commensal microflora-induced T cell responses mediate progressive neurodegeneration in glaucoma
- Huihui Chen,
- Kin-Sang Cho,
- T. H. Khanh Vu,
- Ching-Hung Shen,
- Mandeep Kaur,
- Guochun Chen,
- Rose Mathew,
- M. Lisa McHam,
- Ahad Fazelat,
- Kameran Lashkari,
- Ngan Pan Bennett Au,
- Joyce Ka Yu Tse,
- Yingqian Li,
- Honghua Yu,
- Lanbo Yang,
- Joan Stein-Streilein,
- Chi Him Eddie Ma,
- Clifford J. Woolf,
- Mark T. Whary,
- Martine J. Jager,
- James G. Fox,
- Jianzhu Chen,
- Dong F. Chen
Affiliations
- Huihui Chen
- Department of Ophthalmology, Second Xiangya Hospital of Central South University Changsha
- Kin-Sang Cho
- Schepens Eye Research Institute of Massachusetts Eye and Ear, Harvard Medical School
- T. H. Khanh Vu
- Schepens Eye Research Institute of Massachusetts Eye and Ear, Harvard Medical School
- Ching-Hung Shen
- Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
- Mandeep Kaur
- Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
- Guochun Chen
- Schepens Eye Research Institute of Massachusetts Eye and Ear, Harvard Medical School
- Rose Mathew
- Schepens Eye Research Institute of Massachusetts Eye and Ear, Harvard Medical School
- M. Lisa McHam
- Massachusetts Eye Health Service
- Ahad Fazelat
- Schepens Eye Research Institute of Massachusetts Eye and Ear, Harvard Medical School
- Kameran Lashkari
- Schepens Eye Research Institute of Massachusetts Eye and Ear, Harvard Medical School
- Ngan Pan Bennett Au
- Department of Biomedical Sciences, City University of Hong Kong
- Joyce Ka Yu Tse
- Department of Biomedical Sciences, City University of Hong Kong
- Yingqian Li
- Schepens Eye Research Institute of Massachusetts Eye and Ear, Harvard Medical School
- Honghua Yu
- Schepens Eye Research Institute of Massachusetts Eye and Ear, Harvard Medical School
- Lanbo Yang
- Schepens Eye Research Institute of Massachusetts Eye and Ear, Harvard Medical School
- Joan Stein-Streilein
- Schepens Eye Research Institute of Massachusetts Eye and Ear, Harvard Medical School
- Chi Him Eddie Ma
- Department of Biomedical Sciences, City University of Hong Kong
- Clifford J. Woolf
- F.M. Kirby Neurobiology Center, Children’s Hospital Boston, Harvard Medical School
- Mark T. Whary
- Department of Biological Engineering, Massachusetts Institute of Technology
- Martine J. Jager
- Department of Ophthalmology, Leiden University Medical Center
- James G. Fox
- Department of Biological Engineering, Massachusetts Institute of Technology
- Jianzhu Chen
- Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
- Dong F. Chen
- Schepens Eye Research Institute of Massachusetts Eye and Ear, Harvard Medical School
- DOI
- https://doi.org/10.1038/s41467-018-05681-9
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 13
Abstract
Glaucoma is a neurodegenerative disease of which the etiology is still unclear. Here the authors show that elevation of intraocular pressure induces T cell infiltration in the eyes. Furthermore, they show that T cell cross-reactivity between endogenous and commensal antigens contributes to disease onset in mice.
