Identification of significant chromatin contacts from HiChIP data by FitHiChIP

Sourya Bhattacharyya; Vivek Chandra; Pandurangan Vijayanand; Ferhat Ay

doi:10.1038/s41467-019-11950-y

Nature Communications (Sep 2019)

Identification of significant chromatin contacts from HiChIP data by FitHiChIP

Sourya Bhattacharyya,
Vivek Chandra,
Pandurangan Vijayanand,
Ferhat Ay

Affiliations

Sourya Bhattacharyya: Division of Vaccine Discovery, La Jolla Institute for Immunology
Vivek Chandra: Division of Vaccine Discovery, La Jolla Institute for Immunology
Pandurangan Vijayanand: Division of Vaccine Discovery, La Jolla Institute for Immunology
Ferhat Ay: Division of Vaccine Discovery, La Jolla Institute for Immunology

DOI: https://doi.org/10.1038/s41467-019-11950-y
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 14

Abstract

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HiChIP/PLAC-seq assay is popular for profiling 3D genome interactions among regulatory elements at kilobase resolution. Here the authors describe FitHiChIP an empirical null-based, flexible computational method for statistical significance estimation and loop calling from HiChIP data.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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