Diabetes, Metabolic Syndrome and Obesity (Oct 2023)
The Relationship Between Bone Metabolism and Peripheral Artery Disease in Patients on Hemodialysis: The Potential Role of Osteocalcin
Abstract
Zi-Ye Chen,1 Jie Yang,1 Chen-Yang Tian,2 Wei Jia2 1Department of Nephrology, Beijing Jishuitan Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Department of Vascular Surgery, Beijing Jishuitan Hospital, Capital Medical University, Beijing, People’s Republic of ChinaCorrespondence: Zi-Ye Chen, Department of Nephrology, Beijing Jishuitan Hospital, Capital Medical University, Xinjiekou No. 31 East Street, Xicheng District, Beijing, 100035, People’s Republic of China, Tel +86-13681058086, Email [email protected]: To examine the factors associated with PAD, with a specific focus on bone metabolism factors such as osteocalcin.Methods: This cross-sectional study examined factors about demographic, clinical, and laboratory parameters including bone metabolism biomarkers in hemodialysis patients. The ankle-brachial index (ABI) was measured in all patients, with PAD diagnosed as an ABI < 0.9.Results: Out of the 71 patients, PAD was found in 23 individuals. These patients had an average age of 63.5± 13.0 years, with 59.2% being male. Compared to non-PAD patients, those with PAD were older, had a lower proportion of males, and had a higher prevalence of diabetes and coronary artery disease. Among the factors related to bone metabolism, only osteocalcin exhibited a significant increase in the PAD group compared to the non-PAD group.Conclusion: PAD in patients on hemodialysis was independently linked to high levels of osteocalcin in the bloodstream, indicating the presence of bone metabolism disorders.Keywords: hemodialysis, osteocalcin, bone metabolism disorder, peripheral artery disease
