UV-photochemistry of the biologically relevant thiol group and the disulfide bond: Evolution of early photoproducts from picosecond X-ray absorption spectroscopy at the sulfur K-Edge

Ochmann Miguel; Hussain Abid; von Ahnen Inga; Cordones Amy A.; Hong Kiryong; Lee Jae Hyuk; Ma Rory; Adamczyk Katrin; Kim Tae Kyu; Schoenlein Robert W.; Vendrell Oriol; Huse Nils

doi:10.1051/epjconf/201920509006

EPJ Web of Conferences (Jan 2019)

UV-photochemistry of the biologically relevant thiol group and the disulfide bond: Evolution of early photoproducts from picosecond X-ray absorption spectroscopy at the sulfur K-Edge

Ochmann Miguel,
Hussain Abid,
von Ahnen Inga,
Cordones Amy A.,
Hong Kiryong,
Lee Jae Hyuk,
Ma Rory,
Adamczyk Katrin,
Kim Tae Kyu,
Schoenlein Robert W.,
Vendrell Oriol,
Huse Nils

Affiliations

Ochmann Miguel: Department of Physics, University of Hamburg and Max Planck Institute for the Structure and Dynamics of Matter, Center for Free Electron Laser Science
Hussain Abid: Department of Physics, University of Hamburg and Max Planck Institute for the Structure and Dynamics of Matter, Center for Free Electron Laser Science
von Ahnen Inga: Department of Physics, University of Hamburg and Max Planck Institute for the Structure and Dynamics of Matter, Center for Free Electron Laser Science
Cordones Amy A.: Ultrafast X-ray Science Lab, Chemical Sciences Division, Lawrence Berkeley National Laboratory
Hong Kiryong: Department of Chemistry and Chemistry Institute of Functional Materials, Pusan National University
Lee Jae Hyuk: Ultrafast X-ray Science Lab, Chemical Sciences Division, Lawrence Berkeley National Laboratory
Ma Rory: Department of Chemistry and Chemistry Institute of Functional Materials, Pusan National University
Adamczyk Katrin: Department of Physics, University of Hamburg and Max Planck Institute for the Structure and Dynamics of Matter, Center for Free Electron Laser Science
Kim Tae Kyu: Department of Chemistry and Chemistry Institute of Functional Materials, Pusan National University
Schoenlein Robert W.: Ultrafast X-ray Science Lab, Chemical Sciences Division, Lawrence Berkeley National Laboratory
Vendrell Oriol: Center for Free-Electron Laser Science, DESY and The Hamburg Centre for Ultrafast Imaging
Huse Nils: Department of Physics, University of Hamburg and Max Planck Institute for the Structure and Dynamics of Matter, Center for Free Electron Laser Science

DOI: https://doi.org/10.1051/epjconf/201920509006
Journal volume & issue: Vol. 205
p. 09006

Abstract

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We report on the UV-induced photochemistry of the biologically relevant sulfur-containing thiol group and the disulfide bond in solution using picosecond X-ray absorption spectroscopy at the sulfur K-edge. This study provides element-specific insight into the 267-nm induced photo-chemistry of two model compounds, an aromatic thiol and an aliphatic disulfide. Our transient spectra point to two primary and several secondary photoproducts, and our analysis may aid in understanding UV damage in proteins.

Published in EPJ Web of Conferences

ISSN: 2100-014X (Online)
Publisher: EDP Sciences
Country of publisher: France
LCC subjects: Science: Physics
Website: http://www.epj-conferences.org/

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