Loss of the transcription factor RBPJ induces disease-promoting properties in brain pericytes

Rodrigo Diéguez-Hurtado; Katsuhiro Kato; Benedetto Daniele Giaimo; Melina Nieminen-Kelhä; Hendrik Arf; Francesca Ferrante; Marek Bartkuhn; Tobias Zimmermann; M. Gabriele Bixel; Hanna M. Eilken; Susanne Adams; Tilman Borggrefe; Peter Vajkoczy; Ralf H. Adams

doi:10.1038/s41467-019-10643-w

Nature Communications (Jun 2019)

Loss of the transcription factor RBPJ induces disease-promoting properties in brain pericytes

Rodrigo Diéguez-Hurtado,
Katsuhiro Kato,
Benedetto Daniele Giaimo,
Melina Nieminen-Kelhä,
Hendrik Arf,
Francesca Ferrante,
Marek Bartkuhn,
Tobias Zimmermann,
M. Gabriele Bixel,
Hanna M. Eilken,
Susanne Adams,
Tilman Borggrefe,
Peter Vajkoczy,
Ralf H. Adams

Affiliations

Rodrigo Diéguez-Hurtado: Department of Tissue Morphogenesis, Max Planck Institute for Molecular Biomedicine
Katsuhiro Kato: Department of Tissue Morphogenesis, Max Planck Institute for Molecular Biomedicine
Benedetto Daniele Giaimo: Institute of Biochemistry, University of Giessen
Melina Nieminen-Kelhä: Department of Neurosurgery, Charité-Universitätsmedizin
Hendrik Arf: Department of Tissue Morphogenesis, Max Planck Institute for Molecular Biomedicine
Francesca Ferrante: Institute of Biochemistry, University of Giessen
Marek Bartkuhn: Institute for Genetics, University of Giessen
Tobias Zimmermann: Bioinformatics and Systems Biology, University of Giessen
M. Gabriele Bixel: Department of Tissue Morphogenesis, Max Planck Institute for Molecular Biomedicine
Hanna M. Eilken: Department of Tissue Morphogenesis, Max Planck Institute for Molecular Biomedicine
Susanne Adams: Department of Tissue Morphogenesis, Max Planck Institute for Molecular Biomedicine
Tilman Borggrefe: Institute of Biochemistry, University of Giessen
Peter Vajkoczy: Department of Neurosurgery, Charité-Universitätsmedizin
Ralf H. Adams: Department of Tissue Morphogenesis, Max Planck Institute for Molecular Biomedicine

DOI: https://doi.org/10.1038/s41467-019-10643-w
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 19

Abstract

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Pericytes are perivascular cells essential for blood-brain barrier maintenance. Here Diéguez-Hurtado et al. show that depletion of the transcription factor RBPJ in pericytes affects their molecular identity and disturbs endothelial cell behaviour, inducing the formation of vascular lesions in the brain.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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